Analysis of SIRT1 Expression in Plasma and in an in Vitro Model of Preeclampsia

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorViana-Mattioli, Sarah [UNESP]-
Autor(es): dc.creatorNunes, Priscila [UNESP]-
Autor(es): dc.creatorCavalli, Ricardo-
Autor(es): dc.creatorSandrim, Valeria [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:30:47Z-
Data de disponibilização: dc.date.available2022-02-22T00:30:47Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2019-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1155/2020/4561083-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/200483-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/200483-
Descrição: dc.descriptionPreeclampsia (PE) is a pregnancy-specific disorder that affects 3-8% expecting mothers worldwide being one of the main causes of maternal and fetal morbidity and mortality. The search for altered circulating molecules in PE is an important target to better understand the pathophysiology of this disease. Therefore, we evaluated Sirtuin-1 (SIRT1) concentration in plasma from healthy pregnant (HP) women, gestational hypertensive women (GH), and preeclampsia women (PE) via enzyme-linked immunosorbent assay (ELISA). We also measured intracellular SIRT1 in HUVECs incubated with plasma from PE patients compared to HP and GH via Western Blot Assay. Statistical differences were considered when p<0.05. SIRT1 was downregulated in PE compared to HP and GH, both in plasma and in in vitro assay. Similarly, SIRT1 was also reduced in pregnant women who subsequently developed PE (case) compared to women who had healthy pregnancies (control). This reduction may be indicative of possible underlying pathophysiology mechanisms in PE.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Pharmacology Institute of Biosciences of Botucatu Universidade Estadual Paulista (UNESP) Distrito Rubiao Junior-
Descrição: dc.descriptionMedical School Botucatu Universidade Estadual Paulista (UNESP) Distrito Rubiao Junior Botucatu-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics Faculty of Medicine of Ribeirao Preto University of Sao Paulo-
Descrição: dc.descriptionDepartment of Pharmacology Institute of Biosciences of Botucatu Universidade Estadual Paulista (UNESP) Distrito Rubiao Junior-
Descrição: dc.descriptionMedical School Botucatu Universidade Estadual Paulista (UNESP) Distrito Rubiao Junior Botucatu-
Descrição: dc.descriptionFAPESP: #2008/53593-0-
Descrição: dc.descriptionCNPq: #2014-5/305587-
Descrição: dc.descriptionFAPESP: #2015/20461-8-
Descrição: dc.descriptionFAPESP: #2019/06118-0-
Idioma: dc.languageen-
Relação: dc.relationOxidative Medicine and Cellular Longevity-
???dc.source???: dc.sourceScopus-
Título: dc.titleAnalysis of SIRT1 Expression in Plasma and in an in Vitro Model of Preeclampsia-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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