Atenção: Todas as denúncias são sigilosas e sua identidade será preservada.
Os campos nome e e-mail são de preenchimento opcional
Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.contributor | Federal University of Alagoas (UFAL) | - |
Autor(es): dc.contributor | Feira de Santana State University (UEFS) | - |
Autor(es): dc.creator | Cosme-Silva, L. [UNESP] | - |
Autor(es): dc.creator | Dal Fabbro, Renan [UNESP] | - |
Autor(es): dc.creator | Cintra, L. T.A. [UNESP] | - |
Autor(es): dc.creator | Ervolino, E. [UNESP] | - |
Autor(es): dc.creator | Plazza, F. [UNESP] | - |
Autor(es): dc.creator | Mogami Bomfim, S. [UNESP] | - |
Autor(es): dc.creator | Duarte, P. C.T. | - |
Autor(es): dc.creator | Junior, V. E.D.S. | - |
Autor(es): dc.creator | Gomes Filho, J. E. [UNESP] | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:30:41Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:30:41Z | - |
Data de envio: dc.date.issued | 2020-12-11 | - |
Data de envio: dc.date.issued | 2020-12-11 | - |
Data de envio: dc.date.issued | 2020-08-01 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1111/iej.13311 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/200444 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/200444 | - |
Descrição: dc.description | Aim: To evaluate the relationship between systemic administration of probiotics and inflammation/resorption processes associated with apical periodontitis (AP) in a rat model. Methodology: Twenty-four male Wistar rats were used. AP was induced in the mandibular left/right first molars. The animals were arranged into three groups: Control, Lactobacillus rhamnosus and L. acidophilus. Probiotics were orally administered via gavage (109 colony-forming units (CFU) diluted in 5 mL of water) for 30 days during the development of AP. On the 30th day, blood was collected to analyse the calcium, phosphorus and alkaline phosphatase concentrations in plasma. Then, the animals were euthanized and the jaws removed for micro-computed tomography and immune-histopathological analysis for receptor activator of NF-κB ligand (RANKL), osteoprotegerin (OPG) and tartrate-resistant acid phosphatase (TRAP). After the Shapiro–Wilk test of normality, the Kruskal–Wallis followed by Dunn’s test was performed for nonparametric data, and analysis of variance followed by the Tukey test was performed for parametric data (P < 0.05). Results: There was no significant difference in the calcium and phosphorus levels in plasma amongst the groups (P > 0.05). The level of alkaline phosphatase was significantly higher in the groups that consumed probiotics (P < 0.05). A significantly lower volume of bone resorption was observed in groups that consumed probiotics (P < 0.05). The inflammatory infiltrates and the immunolabelling for RANKL and TRAP were significantly lower in probiotic groups when compared to the control (P < 0.05). Also, the OPG was significantly more immunolabelled in the L. acidophilus group than in the L. rhamnosus and control groups (P < 0.05). Conclusion: Probiotic supplementation through gavage (L. rhamnosus and L. acidophilus) had a significant effect on the reduction of inflammation and bone resorption in apical periodontitis development in rats. | - |
Descrição: dc.description | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
Descrição: dc.description | Department of Endodontics Araçatuba Dental School São Paulo State University (UNESP) | - |
Descrição: dc.description | Department of Odontology School of Dentistry Federal University of Alagoas (UFAL) | - |
Descrição: dc.description | Department of Basic Sciences Araçatuba Dental School São Paulo State University (UNESP) | - |
Descrição: dc.description | Department of Clinic and Surgery and Animal Reproduction Araçatuba Veterinary Medicine São Paulo State University (UNESP) | - |
Descrição: dc.description | Department Health Feira de Santana State University (UEFS) | - |
Descrição: dc.description | Department of Endodontics Araçatuba Dental School São Paulo State University (UNESP) | - |
Descrição: dc.description | Department of Basic Sciences Araçatuba Dental School São Paulo State University (UNESP) | - |
Descrição: dc.description | Department of Clinic and Surgery and Animal Reproduction Araçatuba Veterinary Medicine São Paulo State University (UNESP) | - |
Descrição: dc.description | FAPESP: 2017/08312-2 | - |
Descrição: dc.description | FAPESP: 2017/08314-5 | - |
Formato: dc.format | 1084-1092 | - |
Idioma: dc.language | en | - |
Relação: dc.relation | International Endodontic Journal | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | apical periodontitis | - |
Palavras-chave: dc.subject | Endodontics | - |
Palavras-chave: dc.subject | probiotics | - |
Título: dc.title | Reduced bone resorption and inflammation in apical periodontitis evoked by dietary supplementation with probiotics in rats | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
O Portal eduCAPES é oferecido ao usuário, condicionado à aceitação dos termos, condições e avisos contidos aqui e sem modificações. A CAPES poderá modificar o conteúdo ou formato deste site ou acabar com a sua operação ou suas ferramentas a seu critério único e sem aviso prévio. Ao acessar este portal, você, usuário pessoa física ou jurídica, se declara compreender e aceitar as condições aqui estabelecidas, da seguinte forma: