Protective Effects of Dietary Capsaicin on the Initiation Step of a Two-Stage Hepatocarcinogenesis Rat Model

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorSarmiento-Machado, Luis Manuel [UNESP]-
Autor(es): dc.creatorRomualdo, Guilherme Ribeiro [UNESP]-
Autor(es): dc.creatorZapaterini, Joyce Regina [UNESP]-
Autor(es): dc.creatorTablas, Mariana Baptista [UNESP]-
Autor(es): dc.creatorFernandes, Ana Angélica Henrique [UNESP]-
Autor(es): dc.creatorMoreno, Fernando Salvador-
Autor(es): dc.creatorBarbisan, Luís Fernando [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:30:35Z-
Data de disponibilização: dc.date.available2022-02-22T00:30:35Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2019-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/01635581.2020.1764067-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/200428-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/200428-
Descrição: dc.descriptionCapsaicin (CPS), an ingredient of Capsicum plants, has anti-inflammatory, antioxidant and antitumoral properties. The mechanisms of CPS on hepatocarcinogenesis preclinical bioassays are not described. Thus, the protective effects CPS were evaluated in the early stages of chemically-induced hepatocarcinogenesis. Male Wistar rats received diet containing 0.01% or 0.02% CPS for 3 weeks. Afterwards, animals received a dose of hepatocarcinogen diethylnitrosamine (DEN, 100 mg/kg body weight). From weeks 4–12, groups had their diet replaced by a 0.05% phenobarbital supplemented one to promote DEN-induced preneoplastic lesions. Animals were euthanized 24 h after DEN administration (n = 5/group) or at week 12 (n = 9/group). The estimated CPS intake in rats resembled human consumption. At the end of week 3, dietary 0.02% CPS attenuated DEN-induced oxidative damage and, consequently, hepatocyte necrosis by reducing serum alanine aminotransferase levels, liver CD68-positive macrophages, lipid peroxidation, while increasing antioxidant glutathione system. Additionally, 0.02% CPS upregulated vanilloid Trpv1 receptor and anti-inflammatory epoxygenase Cyp2j4 genes in the liver. Ultimately, previous 0.02% CPS intake decreased the number of GST-P-positive preneoplastic lesions at week 12. Thus, CPS attenuated preneoplastic lesion development, primarily by diminishing DEN-induced oxidative liver injury. Findings indicate that CPS is a promising chemopreventive agent when administered after and during the early stages of hepatocarcinogenesis.-
Descrição: dc.descriptionDepartment of Morphology Biosciences Institute São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment Pathology Medical School São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Chemistry and Biochemistry Biosciences Institute São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Food and Experimental Nutrition Faculty of Pharmaceutical Sciences University of São Paulo (USP)-
Descrição: dc.descriptionDepartment of Morphology Biosciences Institute São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment Pathology Medical School São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Chemistry and Biochemistry Biosciences Institute São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationNutrition and Cancer-
???dc.source???: dc.sourceScopus-
Título: dc.titleProtective Effects of Dietary Capsaicin on the Initiation Step of a Two-Stage Hepatocarcinogenesis Rat Model-
Tipo de arquivo: dc.typelivro digital-
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