Atenção: Todas as denúncias são sigilosas e sua identidade será preservada.
Os campos nome e e-mail são de preenchimento opcional
Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.contributor | Universidade de São Paulo (USP) | - |
Autor(es): dc.creator | Sarmiento-Machado, Luis Manuel [UNESP] | - |
Autor(es): dc.creator | Romualdo, Guilherme Ribeiro [UNESP] | - |
Autor(es): dc.creator | Zapaterini, Joyce Regina [UNESP] | - |
Autor(es): dc.creator | Tablas, Mariana Baptista [UNESP] | - |
Autor(es): dc.creator | Fernandes, Ana Angélica Henrique [UNESP] | - |
Autor(es): dc.creator | Moreno, Fernando Salvador | - |
Autor(es): dc.creator | Barbisan, Luís Fernando [UNESP] | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:30:35Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:30:35Z | - |
Data de envio: dc.date.issued | 2020-12-11 | - |
Data de envio: dc.date.issued | 2020-12-11 | - |
Data de envio: dc.date.issued | 2019-12-31 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1080/01635581.2020.1764067 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/200428 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/200428 | - |
Descrição: dc.description | Capsaicin (CPS), an ingredient of Capsicum plants, has anti-inflammatory, antioxidant and antitumoral properties. The mechanisms of CPS on hepatocarcinogenesis preclinical bioassays are not described. Thus, the protective effects CPS were evaluated in the early stages of chemically-induced hepatocarcinogenesis. Male Wistar rats received diet containing 0.01% or 0.02% CPS for 3 weeks. Afterwards, animals received a dose of hepatocarcinogen diethylnitrosamine (DEN, 100 mg/kg body weight). From weeks 4–12, groups had their diet replaced by a 0.05% phenobarbital supplemented one to promote DEN-induced preneoplastic lesions. Animals were euthanized 24 h after DEN administration (n = 5/group) or at week 12 (n = 9/group). The estimated CPS intake in rats resembled human consumption. At the end of week 3, dietary 0.02% CPS attenuated DEN-induced oxidative damage and, consequently, hepatocyte necrosis by reducing serum alanine aminotransferase levels, liver CD68-positive macrophages, lipid peroxidation, while increasing antioxidant glutathione system. Additionally, 0.02% CPS upregulated vanilloid Trpv1 receptor and anti-inflammatory epoxygenase Cyp2j4 genes in the liver. Ultimately, previous 0.02% CPS intake decreased the number of GST-P-positive preneoplastic lesions at week 12. Thus, CPS attenuated preneoplastic lesion development, primarily by diminishing DEN-induced oxidative liver injury. Findings indicate that CPS is a promising chemopreventive agent when administered after and during the early stages of hepatocarcinogenesis. | - |
Descrição: dc.description | Department of Morphology Biosciences Institute São Paulo State University (UNESP) | - |
Descrição: dc.description | Department Pathology Medical School São Paulo State University (UNESP) | - |
Descrição: dc.description | Department of Chemistry and Biochemistry Biosciences Institute São Paulo State University (UNESP) | - |
Descrição: dc.description | Department of Food and Experimental Nutrition Faculty of Pharmaceutical Sciences University of São Paulo (USP) | - |
Descrição: dc.description | Department of Morphology Biosciences Institute São Paulo State University (UNESP) | - |
Descrição: dc.description | Department Pathology Medical School São Paulo State University (UNESP) | - |
Descrição: dc.description | Department of Chemistry and Biochemistry Biosciences Institute São Paulo State University (UNESP) | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Nutrition and Cancer | - |
???dc.source???: dc.source | Scopus | - |
Título: dc.title | Protective Effects of Dietary Capsaicin on the Initiation Step of a Two-Stage Hepatocarcinogenesis Rat Model | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
O Portal eduCAPES é oferecido ao usuário, condicionado à aceitação dos termos, condições e avisos contidos aqui e sem modificações. A CAPES poderá modificar o conteúdo ou formato deste site ou acabar com a sua operação ou suas ferramentas a seu critério único e sem aviso prévio. Ao acessar este portal, você, usuário pessoa física ou jurídica, se declara compreender e aceitar as condições aqui estabelecidas, da seguinte forma: