Androgen sensitivity gateway to COVID-19 disease severity

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorWarren Alpert Medical School of Brown University-
Autor(es): dc.contributorInc.-
Autor(es): dc.contributorHospital Universitario Ramón y Cajal-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorBrown University-
Autor(es): dc.creatorWambier, Carlos Gustavo-
Autor(es): dc.creatorGoren, Andy-
Autor(es): dc.creatorVaño-Galván, Sergio-
Autor(es): dc.creatorRamos, Paulo Müller [UNESP]-
Autor(es): dc.creatorOssimetha, Angelina-
Autor(es): dc.creatorNau, Gerard-
Autor(es): dc.creatorHerrera, Sabina-
Autor(es): dc.creatorMcCoy, John-
Data de aceite: dc.date.accessioned2022-02-22T00:30:31Z-
Data de disponibilização: dc.date.available2022-02-22T00:30:31Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2019-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/ddr.21688-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/200405-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/200405-
Descrição: dc.descriptionIn this communication, we present arguments for androgen sensitivity as a likely determinant of COVID-19 disease severity. The androgen sensitivity model explains why males are more likely to develop severe symptoms while children are ostensibly resistant to infection. Further, the model explains the difference in COVID-19 mortality rates among different ethnicities. Androgen sensitivity is determined by genetic variants of the androgen receptor. The androgen receptor regulates transcription of the transmembrane protease, serine 2 (TMPRSS2), which is required for SARS-CoV-2 infectivity. TMPRSS2 primes the Spike protein of the virus, which has two consequences: diminishing viral recognition by neutralizing antibodies and activating SARS-CoV-2 for virus-cell fusion. Genetic variants that have been associated with androgenetic alopecia, prostate cancer, benign prostatic hyperplasia and polycystic ovary syndrome could be associated with host susceptibility. In addition to theoretical epidemiological and molecular mechanisms, there are reports of high rates of androgenetic alopecia of from hospitalized COVID-19 patients due to severe symptoms. Androgen sensitivity is a likely determinant of COVID-19 disease severity. We believe that the evidence presented in this communication warrants the initiation of trials using anti-androgen agents.-
Descrição: dc.descriptionDepartment of Dermatology Warren Alpert Medical School of Brown University-
Descrição: dc.descriptionApplied Biology Inc.-
Descrição: dc.descriptionTrichology Unit Hospital Universitario Ramón y Cajal-
Descrição: dc.descriptionDepartment of Dermatology and Radiotherapy São Paulo State University – UNESP-
Descrição: dc.descriptionBrown University-
Descrição: dc.descriptionDivision of Infectious Diseases Department of Medicine Warren Alpert Medical School of Brown University-
Descrição: dc.descriptionDepartment of Dermatology and Radiotherapy São Paulo State University – UNESP-
Idioma: dc.languageen-
Relação: dc.relationDrug Development Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectalopecia-
Palavras-chave: dc.subjectandrogens-
Palavras-chave: dc.subjectanti-androgen-
Palavras-chave: dc.subjectclinical trial-
Palavras-chave: dc.subjectCOVID-19-
Palavras-chave: dc.subjectpandemic-
Palavras-chave: dc.subjectSARS-CoV-2-
Palavras-chave: dc.subjectTMPRSS2-
Título: dc.titleAndrogen sensitivity gateway to COVID-19 disease severity-
Aparece nas coleções:Repositório Institucional - Unesp

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