Gestational trophoblastic neoplasia lethality among Brazilian women: A retrospective national cohort study

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorAntonio Pedro University Hospital of Fluminense Federal University-
Autor(es): dc.contributorFluminense Federal University-
Autor(es): dc.contributorMaternity School of Rio de Janeiro Federal University-
Autor(es): dc.contributorClinics Hospital of Goias Federal University-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorIrmandade da Santa Casa de Misericórdia Hospital-
Autor(es): dc.contributorCaxias do Sul University-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorJundiai Medical School-
Autor(es): dc.contributorGuilherme Álvaro Hospital-
Autor(es): dc.contributorClinics Hospital of Acre-
Autor(es): dc.contributorSão Paulo Federal University-
Autor(es): dc.contributorHarvard Medical School-
Autor(es): dc.creatorFreitas, Fernanda-
Autor(es): dc.creatorBraga, Antonio-
Autor(es): dc.creatorViggiano, Mauricio-
Autor(es): dc.creatorVelarde, Luis Guillermo Coca-
Autor(es): dc.creatorMaesta, Izildinha [UNESP]-
Autor(es): dc.creatorUberti, Elza-
Autor(es): dc.creatorMadi, Jose Mauro-
Autor(es): dc.creatorYela, Daniela-
Autor(es): dc.creatorFernandes, Karayna-
Autor(es): dc.creatorSilveira, Eduardo-
Autor(es): dc.creatorLeal, Elaine-
Autor(es): dc.creatorSun, Sue Yazaki-
Autor(es): dc.creatordos Santos Esteves, Ana Paula Vieira-
Autor(es): dc.creatorFilho, Jorge Rezende-
Autor(es): dc.creatorJunior, Joffre Amim-
Autor(es): dc.creatorElias, Kevin M.-
Autor(es): dc.creatorHorowitz, Neil S.-
Autor(es): dc.creatorBerkowitz, Ross S.-
Data de aceite: dc.date.accessioned2022-02-22T00:30:28Z-
Data de disponibilização: dc.date.available2022-02-22T00:30:28Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.ygyno.2020.04.704-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/200390-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/200390-
Descrição: dc.descriptionObjective: To investigate GTN lethality among Brazilian women comparing cases of death by GTN with those who survived, thereby identifying factors associated with GTN lethality. Methods: We retrospectively reviewed medical records of women with GTN treated at ten Brazilian GTN Reference Centers, from January 1960 to December 2017. We evaluated factors associated with death from GTN and used Cox proportional hazards regression models to identify independent variables with significant influence on the risk of death. Results: From 2186 patients with GTN included in this study, 2092 (95.7%) survived and 89 (4%) died due to GTN. When analyzing the relative risk (RR), adjusted for WHO/FIGO score, patients with low risk disease had a significantly higher risk of death if they had choriocarcinoma (RR: 12.40), metastatic disease (RR: 12.57), chemoresistance (RR: 3.18) or initial treatment outside the Reference Center (RR: 12.22). In relation to patients with high-risk GTN, these factors were significantly associated with death due to GTN: the time between the end of antecedent pregnancy and the initiation of chemotherapy (RR: 4.10), metastatic disease (RR: 14.66), especially in brain (RR: 8.73) and liver (RR: 5.76); absence of chemotherapy or initial treatment with single agent chemotherapy (RR: 10.58 and RR: 1.81, respectively), chemoresistance (RR: 3.20) and the initial treatment outside the Reference Center (RR: 28.30). Conclusion: The risk of mortality from low and high-risk GTN can be reduced by referral of these patients to a Reference Center or, if not possible, to involve clinicians in a Reference Center with consultation regarding management.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionRio de Janeiro Trophoblastic Disease Center Maternity School of Rio de Janeiro Federal University Antonio Pedro University Hospital of Fluminense Federal University-
Descrição: dc.descriptionPostgraduate Program in Medical Sciences Fluminense Federal University-
Descrição: dc.descriptionPostgraduate Program in Perinatal Health Faculty of Medicine Maternity School of Rio de Janeiro Federal University-
Descrição: dc.descriptionGoiania Trophoblastic Disease Center Clinics Hospital of Goias Federal University-
Descrição: dc.descriptionBotucatu Trophoblastic Disease Center Clinical Hospital of Botucatu Medical School Department of Gynecology and Obstetrics São Paulo State University-UNESP-
Descrição: dc.descriptionPorto Alegre Trophoblastic Disease Center Mario Totta Maternity Ward Irmandade da Santa Casa de Misericórdia Hospital-
Descrição: dc.descriptionCaxias do Sul Trophoblastic Disease Center General Hospital of Caxias do Sul School of Medicine Center for Biological and Health Sciences Caxias do Sul University-
Descrição: dc.descriptionCampinas Trophoblastic Disease Center University of Campinas-
Descrição: dc.descriptionJundiai Trophoblastic Disease Center Jundiai Medical School-
Descrição: dc.descriptionSantos Trophoblastic Disease Center Guilherme Álvaro Hospital-
Descrição: dc.descriptionRio Branco Trophoblastic Disease Center Clinics Hospital of Acre-
Descrição: dc.descriptionSão Paulo Hospital Trophoblastic Disease Center Paulista School of Medicine São Paulo Federal University-
Descrição: dc.descriptionNew England Trophoblastic Disease Center Division of Gynecologic Oncology Department of Obstetrics Gynecology and Reproductive Biology Brigham and Women's Hospital Harvard Medical School-
Descrição: dc.descriptionBotucatu Trophoblastic Disease Center Clinical Hospital of Botucatu Medical School Department of Gynecology and Obstetrics São Paulo State University-UNESP-
Descrição: dc.descriptionCAPES: 001-
Formato: dc.format452-459-
Idioma: dc.languageen-
Relação: dc.relationGynecologic Oncology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBrazil-
Palavras-chave: dc.subjectChemotherapy-
Palavras-chave: dc.subjectChoriocarcinoma-
Palavras-chave: dc.subjectGestational trophoblastic neoplasia-
Palavras-chave: dc.subjectLethality-
Palavras-chave: dc.subjectMortality-
Título: dc.titleGestational trophoblastic neoplasia lethality among Brazilian women: A retrospective national cohort study-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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