Digestion of Intact Gluten Proteins by Bifidobacterium Species: Reduction of Cytotoxicity and Proinflammatory Responses

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Autor(es): dc.contributorUniversidade Federal de São Carlos (UFSCar)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorDe Almeida, Natália Ellen Castilho-
Autor(es): dc.creatorEsteves, Franciele Grego [UNESP]-
Autor(es): dc.creatorDos Santos-Pinto, José Roberto Aparecido [UNESP]-
Autor(es): dc.creatorPeres De Paula, Carla-
Autor(es): dc.creatorDa Cunha, Anderson Ferreira-
Autor(es): dc.creatorMalavazi, Iran-
Autor(es): dc.creatorPalma, Mario Sergio [UNESP]-
Autor(es): dc.creatorRodrigues-Filho, Edson-
Data de aceite: dc.date.accessioned2022-02-22T00:30:27Z-
Data de disponibilização: dc.date.available2022-02-22T00:30:27Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-04-15-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1021/acs.jafc.0c01421-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/200386-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/200386-
Descrição: dc.descriptionCeliac disease (CD) is a chronic illness characterized by an inflammatory process triggered by gluten protein intake. Recent evidence has suggested that the lower relative abundance of bifidobacteria in the intestinal lumen may be associated with CD. Herein, we assessed the effect of the Bifidobacterium species Bifidobacterium bifidum, Bifidobacterium longum, Bembidion breve, Bifidobacterium animalis alone, and also a Bifidobacterium consortium on the digestion of intact gluten proteins (gliadins and glutenins) and the associated immunomodulatory responses elicited by the resulting peptides. The cytotoxicity and proinflammatory responses were evaluated through the activation of NF-kB p65 and the expression of cytokines TNF-α and IL-1β in Caco-2 cell cultures exposed to gluten-derived peptides. The peptides induced a clear reduction in cytotoxic responses and proinflammatory marker levels compared to the gluten fragments generated during noninoculated gastrointestinal digestion. These results highlight the possible use of probiotics based on bifidobacteria as a prospective treatment for CD.-
Descrição: dc.descriptionDepartment of Chemistry Federal University of São Carlos (UFSCar)-
Descrição: dc.descriptionCenter of Study of Social Insects Department of Biology Institute of Biosciences of Rio Claro São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Genetics and Evolution Biotechnology Graduate Program (PPGBiotec) Federal University of São Carlos-
Descrição: dc.descriptionCenter of Study of Social Insects Department of Biology Institute of Biosciences of Rio Claro São Paulo State University (UNESP)-
Formato: dc.format4485-4492-
Idioma: dc.languageen-
Relação: dc.relationJournal of Agricultural and Food Chemistry-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbifidobacteria-
Palavras-chave: dc.subjectceliac disease-
Palavras-chave: dc.subjectgluten proteins-
Palavras-chave: dc.subjectgluten-derived peptides-
Palavras-chave: dc.subjectimmunomodulatory response-
Palavras-chave: dc.subjecttoxicity-
Título: dc.titleDigestion of Intact Gluten Proteins by Bifidobacterium Species: Reduction of Cytotoxicity and Proinflammatory Responses-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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