Cytotoxic and apoptotic effects of ternary silver(i) complexes bearing 2-formylpyridine thiosemicarbazones and 1,10-phenanthroline

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade Federal de São Carlos (UFSCar)-
Autor(es): dc.creatorSilva, Débora E. S. [UNESP]-
Autor(es): dc.creatorBecceneri, Amanda B.-
Autor(es): dc.creatorSolcia, Mariana C. [UNESP]-
Autor(es): dc.creatorSantiago, João V. B. [UNESP]-
Autor(es): dc.creatorMoreira, Mariete B. [UNESP]-
Autor(es): dc.creatorGomes Neto, José A. [UNESP]-
Autor(es): dc.creatorPavan, Fernando R. [UNESP]-
Autor(es): dc.creatorCominetti, Márcia R.-
Autor(es): dc.creatorPereira, José C. M. [UNESP]-
Autor(es): dc.creatorNetto, Adelino V. G. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:30:22Z-
Data de disponibilização: dc.date.available2022-02-22T00:30:22Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-04-28-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1039/d0dt00253d-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/200364-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/200364-
Descrição: dc.descriptionNew silver(i) compounds containing 2-formylpyridine-N(4)-R-thiosemicarbazones and 1,10-phenanthroline (phen) were synthesized and characterized by spectroscopic techniques (IR and NMR), elemental analysis, ESI-MS and molar conductance measurements. In these complexes, both phen and thiosemicarbazone ligands are coordinated in a chelating bidentate fashion. Compounds 1-3 not only showed good in vitro antiproliferative activity against human lung (A549) and breast tumor cells (MDA-MB-231 and MCF-7), with IC50 values ranging from 1.49 to 20.90 μM, but were also demonstrated to be less toxic towards human breast non-tumor cells (MCF-10A). Cellular uptake studies indicated that compounds 1-3 were taken up by the MDA-MB-231 cells in 6 hours. Cell death assays in the MDA-MB-231 cells were conducted with compound 1 aiming to evaluate its effects on cell morphology, induction of apoptosis, the cell cycle, reactive oxygen species (ROS) formation and mitochondrial membrane potential (Δψm). Compound 1 caused morphological changes, such as cell shrinkage and rounding, increased the sub-G1 phase population, and induced apoptotic cell death, ROS formation and loss of mitochondrial membrane potential (Δψm). DNA binding results revealed that 1 interacted with the ct-DNA minor groove. Complexes 1-3 also exhibited good in vitro activity against M. tuberculosis H37Rv, with MIC values ranging from 3.37 to 4.65 μM.-
Descrição: dc.descriptionDepartment of General and Inorganic Chemistry UNESP-São Paulo State University Institute of Chemistry-
Descrição: dc.descriptionDepartment de Gerontology Federal University of São Carlos-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences UNESP-São Paulo State University-
Descrição: dc.descriptionDepartment of General and Inorganic Chemistry UNESP-São Paulo State University Institute of Chemistry-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences UNESP-São Paulo State University-
Formato: dc.format5264-5275-
Idioma: dc.languageen-
Relação: dc.relationDalton Transactions-
???dc.source???: dc.sourceScopus-
Título: dc.titleCytotoxic and apoptotic effects of ternary silver(i) complexes bearing 2-formylpyridine thiosemicarbazones and 1,10-phenanthroline-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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