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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.contributor | Universidade Federal de São Carlos (UFSCar) | - |
Autor(es): dc.creator | Silva, Débora E. S. [UNESP] | - |
Autor(es): dc.creator | Becceneri, Amanda B. | - |
Autor(es): dc.creator | Solcia, Mariana C. [UNESP] | - |
Autor(es): dc.creator | Santiago, João V. B. [UNESP] | - |
Autor(es): dc.creator | Moreira, Mariete B. [UNESP] | - |
Autor(es): dc.creator | Gomes Neto, José A. [UNESP] | - |
Autor(es): dc.creator | Pavan, Fernando R. [UNESP] | - |
Autor(es): dc.creator | Cominetti, Márcia R. | - |
Autor(es): dc.creator | Pereira, José C. M. [UNESP] | - |
Autor(es): dc.creator | Netto, Adelino V. G. [UNESP] | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:30:22Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:30:22Z | - |
Data de envio: dc.date.issued | 2020-12-11 | - |
Data de envio: dc.date.issued | 2020-12-11 | - |
Data de envio: dc.date.issued | 2020-04-28 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1039/d0dt00253d | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/200364 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/200364 | - |
Descrição: dc.description | New silver(i) compounds containing 2-formylpyridine-N(4)-R-thiosemicarbazones and 1,10-phenanthroline (phen) were synthesized and characterized by spectroscopic techniques (IR and NMR), elemental analysis, ESI-MS and molar conductance measurements. In these complexes, both phen and thiosemicarbazone ligands are coordinated in a chelating bidentate fashion. Compounds 1-3 not only showed good in vitro antiproliferative activity against human lung (A549) and breast tumor cells (MDA-MB-231 and MCF-7), with IC50 values ranging from 1.49 to 20.90 μM, but were also demonstrated to be less toxic towards human breast non-tumor cells (MCF-10A). Cellular uptake studies indicated that compounds 1-3 were taken up by the MDA-MB-231 cells in 6 hours. Cell death assays in the MDA-MB-231 cells were conducted with compound 1 aiming to evaluate its effects on cell morphology, induction of apoptosis, the cell cycle, reactive oxygen species (ROS) formation and mitochondrial membrane potential (Δψm). Compound 1 caused morphological changes, such as cell shrinkage and rounding, increased the sub-G1 phase population, and induced apoptotic cell death, ROS formation and loss of mitochondrial membrane potential (Δψm). DNA binding results revealed that 1 interacted with the ct-DNA minor groove. Complexes 1-3 also exhibited good in vitro activity against M. tuberculosis H37Rv, with MIC values ranging from 3.37 to 4.65 μM. | - |
Descrição: dc.description | Department of General and Inorganic Chemistry UNESP-São Paulo State University Institute of Chemistry | - |
Descrição: dc.description | Department de Gerontology Federal University of São Carlos | - |
Descrição: dc.description | School of Pharmaceutical Sciences UNESP-São Paulo State University | - |
Descrição: dc.description | Department of General and Inorganic Chemistry UNESP-São Paulo State University Institute of Chemistry | - |
Descrição: dc.description | School of Pharmaceutical Sciences UNESP-São Paulo State University | - |
Formato: dc.format | 5264-5275 | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Dalton Transactions | - |
???dc.source???: dc.source | Scopus | - |
Título: dc.title | Cytotoxic and apoptotic effects of ternary silver(i) complexes bearing 2-formylpyridine thiosemicarbazones and 1,10-phenanthroline | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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