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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Jundiaí School of Medicine | - |
Autor(es): dc.contributor | ABC School of Medicine | - |
Autor(es): dc.contributor | Federal University of Parana | - |
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.contributor | Universidade de São Paulo (USP) | - |
Autor(es): dc.contributor | Federal University of Rio Grande do Sul | - |
Autor(es): dc.contributor | Libbs Farmacêutica Ltda | - |
Autor(es): dc.creator | Machado, Rogerio Bonassi | - |
Autor(es): dc.creator | Pompei, Luciano De Melo | - |
Autor(es): dc.creator | Andrade, Rosires | - |
Autor(es): dc.creator | Nahas, Eliana [UNESP] | - |
Autor(es): dc.creator | Guazzelli, Cristina | - |
Autor(es): dc.creator | Wender, Maria Celeste | - |
Autor(es): dc.creator | Cruz, Achilles Machado | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:30:17Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:30:17Z | - |
Data de envio: dc.date.issued | 2020-12-11 | - |
Data de envio: dc.date.issued | 2020-12-11 | - |
Data de envio: dc.date.issued | 2019-12-31 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.2147/IJWH.S238294 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/200341 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/200341 | - |
Descrição: dc.description | Objective: To compare the bleeding pattern in women using ethinylestradiol 20 mcg/ drospirenone 3 mg (EE 20 mcg/DRSP 3 mg) in a 24/4-day cyclic regimen with an extended regimen. Unexpected bleeding/spotting in the extended regimen group was managed by allowing a 4-day hormone-free interval (HFI). Methods: This was a randomized, prospective, open-label, multicenter study. Participants (N = 348) were randomized to receive EE 20 mcg/DRSP 3 mg in either an extended regimen (EE/DRSPes group) or a 24/4-day cyclic regimen (EE/DRSP24/4 group) and followed for 168 days. In the EE/DRSPes group, a 4-day HFI was allowed whenever unexpected bleeding/ spotting persisted for ≥7 consecutive days. The participants assessed their bleeding daily as “no bleeding,” “spotting,” or “light,” “moderate,” or “heavy” bleeding according to a predefined scale. Results: EE/DRSPes group experienced fewer days of bleeding than those using a 24/4 cyclic regimen (P < 0.001). After 168 days, 57.5% of women in the EE/DRSPes group achieved complete amenorrhea (i.e., neither bleeding nor spotting) and 73.9% achieved “no bleeding” (i.e., no bleeding with or without spotting) during the final 28-day interval of the study period. Women in the extended group who instituted the 4-day HFI experienced a 94.1% rate of successful management of unexpected bleeding/spotting. Conclusion: The use of EE 20 mcg/DRSP 3 mg in an extended regimen resulted in high rates of amenorrhea and “no bleeding”. Unexpected bleeding/spotting in the EE/DRSPes group could be managed effectively with a 4-day HFI. Clinical Trial Registration: International Standard Randomised Controlled Trial Number (ISRCTN57661673): http://www.controlled-trials.com/isrctn/pf/57661673. | - |
Descrição: dc.description | Department of Gynecology and Obstetrics Jundiaí School of Medicine | - |
Descrição: dc.description | Department of Gynecology and Obstetrics ABC School of Medicine | - |
Descrição: dc.description | Department of Gynecology and Obstetrics Federal University of Parana | - |
Descrição: dc.description | Department of Gynecology and Obstetrics Botucatu Medical School (Unesp) | - |
Descrição: dc.description | Department of Obstetrics Federal University of Sao Paulo | - |
Descrição: dc.description | Department of Gynecology and Obstetrics Federal University of Rio Grande do Sul | - |
Descrição: dc.description | Department of Clinical Research Libbs Farmacêutica Ltda | - |
Descrição: dc.description | Department of Gynecology and Obstetrics Botucatu Medical School (Unesp) | - |
Formato: dc.format | 235-242 | - |
Idioma: dc.language | en | - |
Relação: dc.relation | International Journal of Women's Health | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | Bleeding profile | - |
Palavras-chave: dc.subject | Combined oral contraceptives | - |
Palavras-chave: dc.subject | Drospirenone | - |
Palavras-chave: dc.subject | Extended regimen | - |
Palavras-chave: dc.subject | Low dose oral contraceptive | - |
Título: dc.title | Bleeding pattern and management of unexpected bleeding/spotting with an extended regimen of a combination of ethinylestradiol 20 mcg and drospirenone 3 mg | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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