Leaching of benzimidazole antiparasitics in soil columns and in soil columns amended with sheep excreta

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorPorto, Rafael Silveira-
Autor(es): dc.creatorPinheiro, Rafael Silvio Bonilha [UNESP]-
Autor(es): dc.creatorRath, Susanne-
Data de aceite: dc.date.accessioned2022-02-22T00:30:06Z-
Data de disponibilização: dc.date.available2022-02-22T00:30:06Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2019-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s11356-020-08389-w-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/200295-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/200295-
Descrição: dc.descriptionBenzimidazoles are anthelmintics frequently used in sheep farming due to the high susceptibility of these animals to parasitic diseases. Sheep excreta are often disposed onto soils as a fertilizer, and they may contain benzimidazole residues that can contaminate soil and water. This work aimed to assess the leaching behavior of benzimidazole drugs (albendazole, fenbendazole, and thiabendazole) and their metabolites in two Brazilian soils of different textural classifications (sandy and clay), as well as sheep excreta-amended soils, following the OECD 312 Guidelines. Ewes received a single oral dose of 10 mg kg−1 b.w. of either albendazole or fenbendazole. The feces were collected at 24, 48, 72, 96, and 120 h post-dose, and the parent drugs and their metabolites extracted using the QuEChERS approach and quantified by UHPLC-MS/MS. For the leaching assays, a benzimidazole solution was directly applied onto the soil columns, or an amount of 5 g of the medicated sheep feces was distributed over the top of the soil columns. In soil samples, benzimidazoles were extracted by solid-liquid extraction and quantified by UHPLC-MS/MS. For the leaching studies, atrazine was used as a reference substance to determine the relative mobility factor of the analytes of interest. Benzimidazoles were considered slightly to moderately mobile in both soils tested, with a leaching distance of up to 25 cm in a 30-cm soil column. Approximately 3 to 6% of the benzimidazoles present in ewe feces were able to leach into the soil columns. This finding is of concern since benzimidazoles are persistent in soil and may pose a risk to soil biota and induce the development of resistant strains of parasites.-
Descrição: dc.descriptionInstitute of Chemistry Department of Analytical Chemistry University of Campinas, P.O. Box 6154-
Descrição: dc.descriptionDepartment of Biology and Animal Science São Paulo State University (UNESP) School of Engineering (FEIS)-
Descrição: dc.descriptionDepartment of Biology and Animal Science São Paulo State University (UNESP) School of Engineering (FEIS)-
Idioma: dc.languageen-
Relação: dc.relationEnvironmental Science and Pollution Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBenzimidazoles and metabolites-
Palavras-chave: dc.subjectBrazilian soils-
Palavras-chave: dc.subjectLeaching behavior-
Palavras-chave: dc.subjectMobility in soil-
Palavras-chave: dc.subjectSheep feces-
Palavras-chave: dc.subjectUHPLC-MS/MS-
Título: dc.titleLeaching of benzimidazole antiparasitics in soil columns and in soil columns amended with sheep excreta-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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