Assembly and antifungal effect of a new fluconazole-carrier nanosystem

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversity of Western São Paulo (UNOESTE)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorChemi Engenharia de Materiais-
Autor(es): dc.contributorUniversidade Federal de São Carlos (UFSCar)-
Autor(es): dc.creatorDe Lima, Taynara M.T.-
Autor(es): dc.creatorArias, Laís S. [UNESP]-
Autor(es): dc.creatorAfanaci, Letícia F.-
Autor(es): dc.creatorFerraresse, Raphael F.B.-
Autor(es): dc.creatorDe Neto, Francisco N.S. [UNESP]-
Autor(es): dc.creatorDe Lima, Bruno H.R.-
Autor(es): dc.creatorStraioto, Fabiana G.-
Autor(es): dc.creatorDe Camargo, Emerson R.-
Autor(es): dc.creatorPessan, Juliano P. [UNESP]-
Autor(es): dc.creatorMonteiro, Douglas R.-
Data de aceite: dc.date.accessioned2022-02-22T00:30:05Z-
Data de disponibilização: dc.date.available2022-02-22T00:30:05Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.2217/fmb-2019-0182-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/200287-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/200287-
Descrição: dc.descriptionAim: To assemble, characterize and assess the antifungal effects of a new fluconazole (FLZ)-carrier nanosystem. Materials & methods: The nanosystem was prepared by loading FLZ on chitosan (CS)-coated iron oxide nanoparticles (IONPs). Antifungal effects were evaluated on planktonic cells (by minimum inhibitory concentration determination) and on biofilms (by quantification of cultivable cells, total biomass, metabolism and extracellular matrix) of Candida albicans and Candida glabrata. Results: Characterization results ratified the formation of a nanosystem (<320 nm) with FLZ successfully embedded. IONPs-CS-FLZ nanosystem reduced minimum inhibitory concentration values and, in general, showed similar antibiofilm effects compared with FLZ alone. Conclusion: IONPs-CS-FLZ nanosystem was more effective than FLZ mainly in inhibiting Candida planktonic cells. This nanocarrier has potential to fight fungal infections.-
Descrição: dc.descriptionGraduate Program in Dentistry (GPD - Master's Degree) University of Western São Paulo (UNOESTE)-
Descrição: dc.descriptionDepartment of Preventive and Restorative Dentistry School of Dentistry Araçatuba São Paulo State University (Unesp)-
Descrição: dc.descriptionSchool of Dentistry Presidente Prudente University of Western São Paulo (UNOESTE)-
Descrição: dc.descriptionChemi Engenharia de Materiais-
Descrição: dc.descriptionDepartment of Chemistry Federal University of São Carlos (UFSCar)-
Descrição: dc.descriptionDepartment of Preventive and Restorative Dentistry School of Dentistry Araçatuba São Paulo State University (Unesp)-
Formato: dc.format273-285-
Idioma: dc.languageen-
Relação: dc.relationFuture Microbiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbiofilms-
Palavras-chave: dc.subjectCandida-
Palavras-chave: dc.subjectchitosan-
Palavras-chave: dc.subjectfluconazole-
Palavras-chave: dc.subjectiron oxide nanoparticles-
Título: dc.titleAssembly and antifungal effect of a new fluconazole-carrier nanosystem-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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