Exercise Training Attenuates Cirrhotic Cardiomyopathy

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorFederal University of Mato Grosso (UFMT)-
Autor(es): dc.creatorde Souza, Sérgio Luiz Borges [UNESP]-
Autor(es): dc.creatorMota, Gustavo Augusto Ferreira [UNESP]-
Autor(es): dc.creatorGregolin, Cristina Schmitt-
Autor(es): dc.creatordo Nascimento, Milena-
Autor(es): dc.creatorLuvizotto, Renata Azevedo Melo-
Autor(es): dc.creatorBazan, Silmeia Garcia Zanati [UNESP]-
Autor(es): dc.creatorSugizaki, Mário Mateus-
Autor(es): dc.creatorBarbisan, Luis Fernando [UNESP]-
Autor(es): dc.creatorCicogna, Antonio Carlos [UNESP]-
Autor(es): dc.creatordo Nascimento, André Ferreira-
Data de aceite: dc.date.accessioned2022-02-22T00:30:01Z-
Data de disponibilização: dc.date.available2022-02-22T00:30:01Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2019-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s12265-020-09997-0-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/200270-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/200270-
Descrição: dc.descriptionCirrhotic cardiomyopathy is a condition where liver cirrhosis is associated with cardiac dysfunction. Triggers and blockers of cirrhotic cardiomyopathy are poorly understood, which might compromise the prognosis of chronic liver disease patients. We tested whether exercise training would reduce liver damage induced by thioacetamide and prevent liver cirrhosis-associated cardiomyopathy. Wistar rats were divided into three groups: control, thioacetamide (TAA), or TAA plus exercise. Thioacetamide increased liver weight and serum alanine aminotransferase and aspartate aminotransferase levels. Also, TAA treatment was involved with hepatic nodule formation, fibrotic septa, inflammatory infiltration, and hepatocyte necrosis. The exercise group presented with a reduction in liver injury status. We found that liver injury was associated with disordered cardiac hypertrophy as well as diastolic and systolic dysfunction. Exercise training attenuated cirrhosis-associated cardiac remodeling and diastolic dysfunction and prevented systolic impairment. These results provided insights that exercise training can mitigate cirrhotic cardiomyopathy phenotype. [Figure not available: see fulltext.].-
Descrição: dc.descriptionDepartment of Internal Medicine Botucatu School of Medicine São Paulo State University (UNESP), Botucatu-
Descrição: dc.descriptionInstitute of Health Sciences Federal University of Mato Grosso (UFMT), Avenida Alexandre Ferronato, n°1200, Setor Industrial-
Descrição: dc.descriptionDepartment of Morphology Institute of Biosciences Sao Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Internal Medicine Botucatu School of Medicine São Paulo State University (UNESP), Botucatu-
Descrição: dc.descriptionDepartment of Morphology Institute of Biosciences Sao Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationJournal of Cardiovascular Translational Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCardiac dysfunction-
Palavras-chave: dc.subjectCirrhotic cardiomyopathy-
Palavras-chave: dc.subjectExercise training-
Palavras-chave: dc.subjectLiver cirrhosis-
Palavras-chave: dc.subjectThioacetamide-
Título: dc.titleExercise Training Attenuates Cirrhotic Cardiomyopathy-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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