Cyto-genotoxic evaluation of novel anti-tubercular copper (II) complexes containing isoniazid-based ligands

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Autor(es): dc.contributorUNIARA- University of Araraquara-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorFregonezi, Nathália Ferreira-
Autor(es): dc.creatorAparecida de Souza, Fabiana-
Autor(es): dc.creatorAleixo, Nadia Andrade-
Autor(es): dc.creatorStefany da Silva Gomes, Pietra-
Autor(es): dc.creatorSilvestre, Rafaela Baldassari-
Autor(es): dc.creatorDe Grandis, Rone Aparecido [UNESP]-
Autor(es): dc.creatorBento da Silva, Patricia [UNESP]-
Autor(es): dc.creatorPavan, Fernando Rogério [UNESP]-
Autor(es): dc.creatorChorilli, Marlus [UNESP]-
Autor(es): dc.creatorResende, Flavia Aparecida-
Data de aceite: dc.date.accessioned2022-02-22T00:29:55Z-
Data de disponibilização: dc.date.available2022-02-22T00:29:55Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-06-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.yrtph.2020.104653-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/200243-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/200243-
Descrição: dc.descriptionConsidering the promising previous results of Cu (II) complexes with isoniazid active ligand against Mycobacterium tuberculosis, the main causative agent of tuberculosis, novel biological assays evaluating its toxicogenic potential were performed to ensure the safe use. The genotoxicity/mutagenicity of the complexes CuCl2(INH)2.H2O (I1), Cu(NCS)2(INH)2.5H2O (I2) and Cu(NCO)2(INH)2.4H2O (I3) was evaluated by the Comet, Micronucleus-cytome and Salmonella microsome (Ames test) assays. The cell viability using resazurin assay indicated that I1, I2 e I3 had moderate to low capacity to reduce the viability of colorectal cells (Caco-2), liver cells (HepG2), lung cells (GM 07492-A and A549) and endothelial cells (HU-VE-C). On genotoxicity/mutagenicity, I1 complex did not induce sizable levels of DNA damage in HepG2 cells (Comet assay), and gene (Ames test) and chromosomal (Micronucleus-cytome assay) mutations. Already, I2 and I3 complexes were considered mutagenic in the highest concentrations used. In light of the above, these results contribute to valuable data on the safe use of Cu(II) complexes. Considering the absence of mutagenicity and cytotoxicity of I1, this complex is a potential candidate for the development of a new drug to the treatment tuberculosis, while I2 and I3 require caution in its use.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionASCRS Research Foundation-
Descrição: dc.descriptionUNIARA- University of Araraquara Department of Biological Sciences and Health-
Descrição: dc.descriptionUNESP-São Paulo State University Faculty of Pharmaceutical Sciences of Araraquara- Department of Biological Sciences-
Descrição: dc.descriptionUNESP-São Paulo State University Faculty of Pharmaceutical Sciences of Araraquara- Department of Biological Sciences-
Descrição: dc.descriptionFAPESP: 2013/09265-7-
Descrição: dc.descriptionASCRS Research Foundation: 2017/16278-9-
Descrição: dc.descriptionFAPESP: 2017/16278-9-
Descrição: dc.descriptionASCRS Research Foundation: D:\MYFILES\ELSEVIER\YRTPH\00104653\S-CESTRUCTURING\gs3-
Idioma: dc.languageen-
Relação: dc.relationRegulatory Toxicology and Pharmacology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAmes test-
Palavras-chave: dc.subjectCitotoxicity-
Palavras-chave: dc.subjectComet assay-
Palavras-chave: dc.subjectCopper(II) complexes-
Palavras-chave: dc.subjectMicronucleus-cytome assay-
Título: dc.titleCyto-genotoxic evaluation of novel anti-tubercular copper (II) complexes containing isoniazid-based ligands-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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