Long-term sucrose solution consumption causes metabolic alterations and affects hepatic oxidative stress in Wistar rats

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Autor(es): dc.contributorLuiz Meneghel Campus-
Autor(es): dc.contributorUniversidade Estadual de Maringá (UEM)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade Estadual de Londrina (UEL)-
Autor(es): dc.creatorCruz, Ellen Mayara Souza-
Autor(es): dc.creatorMorais, Juliana Maria Bitencourt De-
Autor(es): dc.creatorRosa, Carlos Vinícius Dalto Da-
Autor(es): dc.creatorSimoes, Mellina Da Silva-
Autor(es): dc.creatorComar, Jurandir Fernando-
Autor(es): dc.creatorChuffa, Luiz Gustavo De Almeida [UNESP]-
Autor(es): dc.creatorSeiva, Fábio Rodrigues Ferreira-
Data de aceite: dc.date.accessioned2022-02-22T00:29:54Z-
Data de disponibilização: dc.date.available2022-02-22T00:29:54Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2019-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1242/bio.047282-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/200241-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/200241-
Descrição: dc.descriptionAs the number of overweight and obese people has risen in recent years, there has been a parallel increase in the number of peoplewithmetabolic syndrome, diabetes and non-alcoholic fatty liver disease. The consumption of artificially sweetened beverages contributes to these epidemics. This study investigated the long-term effects of ingestion of a 40% sucrose solution on serum and hepatic parameters in male Wistar rats (Rattus norvegicus). After 180 days, the glycemic response, lipid profile and hepatic oxidative stress were compared to those of rats maintained on water. Sucrose ingestion led to higher body weight, increased fat deposits, reduced voluntary food intake and reduced feeding efficiency. Rats that received sucrose solution showed early signs of glucose intolerance and insulin resistance, such as hyperinsulinemia. Serum triacylglycerol (TG), very-low density lipoprotein (VLDL), cholesterol, ALT and AST levels increased after sucrose consumption. Elevated malondialdehyde and superoxide dismutase (SOD) levels and reduced glutathione levels characterize the hepatic oxidative stress due to sucrose ingestion. Liver sample histology showed vacuolar traces and increased fibrotic tissue. Our data showed the harmful effects of chronic consumption of sucrose solution, which can cause alterations that are found frequently in obesity, glucose intolerance and non-alcoholic hepatic disease, characteristics of metabolic syndrome.-
Descrição: dc.descriptionDepartment of Biology Biological Science Center Universidade Estadual Do Norte Do Paranaì- Uenp Luiz Meneghel Campus-
Descrição: dc.descriptionDepartment of Biochemistry Universidade Estadual de Maringaì - Uem-
Descrição: dc.descriptionDepartment of Anatomy Institute of Biosciences of Botucatu Universidade Estadual Paulista - Unesp-
Descrição: dc.descriptionPost Graduation Program of Experimental Pathology Department of Pathology Universidade Estadual de Londrina - Uel-
Descrição: dc.descriptionDepartment of Anatomy Institute of Biosciences of Botucatu Universidade Estadual Paulista - Unesp-
Idioma: dc.languageen-
Relação: dc.relationBiology Open-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectHepatic tissue-
Palavras-chave: dc.subjectMetabolic syndrome-
Palavras-chave: dc.subjectOxidative stress-
Palavras-chave: dc.subjectSucrose solution-
Título: dc.titleLong-term sucrose solution consumption causes metabolic alterations and affects hepatic oxidative stress in Wistar rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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