Calcitriol Prevents Neuroinflammation and Reduces Blood-Brain Barrier Disruption and Local Macrophage/Microglia Activation

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorde Oliveira, Larissa Ragozo Cardoso [UNESP]-
Autor(es): dc.creatorMimura, Luiza Ayumi Nishiyama [UNESP]-
Autor(es): dc.creatorFraga-Silva, Thais Fernanda de Campos [UNESP]-
Autor(es): dc.creatorIshikawa, Larissa Lumi Watanabe [UNESP]-
Autor(es): dc.creatorFernandes, Ana Angélica Henrique [UNESP]-
Autor(es): dc.creatorZorzella-Pezavento, Sofia Fernanda Gonçalves [UNESP]-
Autor(es): dc.creatorSartori, Alexandrina [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:29:51Z-
Data de disponibilização: dc.date.available2022-02-22T00:29:51Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-03-12-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3389/fphar.2020.00161-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/200231-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/200231-
Descrição: dc.descriptionMultiple sclerosis (MS) is a progressive disease of the central nervous system (CNS) that involves damage to the myelin sheath surrounding axons. MS therapy is based on immunomodulatory drugs that reduce disease recurrence and severity. Vitamin D is a hormone whose immunomodulatory ability has been widely demonstrated, including in experimental autoimmune encephalomyelitis (EAE), which is an animal model of CNS inflammation. In this study, we evaluated the potential of very early intervention with the active form of vitamin D (1,25-dihydroxyvitamin D3) to control neuroinflammation during EAE development. EAE was induced in C57BL/6J mice and 1,25-dihydroxyvitamin D3 administration began 1 day after disease induction. This procedure decreased prevalence, clinical score, inflammation, and demyelination. It also reduced MHCII expression in macrophages and microglia as well as the level of oxidative stress and messenger RNA (mRNA) expression for NLRP3, caspase-1, interleukin (IL)-1β, CX3CR1, CCL17, RORc and Tbx21 at the CNS. Otherwise, mRNA expression for ZO-1 increased at the lumbar spinal cord. These effects were accompanied by the stabilization of blood-spinal cord barrier permeability. The results of this study indicate that early intervention with 1,25-dihydroxyvitamin D3 can control the neuroinflammatory process that is the hallmark of EAE and MS immunopathogenesis and should thus be explored as an adjunct therapy for MS patients.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Tropical Diseases Botucatu Medical School São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Microbiology and Immunology Institute of Biosciences São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Chemistry and Biochemistry Institute of Biosciences São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Tropical Diseases Botucatu Medical School São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Microbiology and Immunology Institute of Biosciences São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Chemistry and Biochemistry Institute of Biosciences São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationFrontiers in Pharmacology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subject1,25-dihydroxyvitamin D3-
Palavras-chave: dc.subjectblood-brain barrier-
Palavras-chave: dc.subjectexperimental autoimmune encephalomyelitis-
Palavras-chave: dc.subjectinflammasome-
Palavras-chave: dc.subjectoxidative stress-
Título: dc.titleCalcitriol Prevents Neuroinflammation and Reduces Blood-Brain Barrier Disruption and Local Macrophage/Microglia Activation-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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