PEGlatyon-SPION surface functionalization with folic acid for magnetic hyperthermia applications

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorInstituto Federal Goiano-
Autor(es): dc.contributorUniversidade de Brasília (UnB)-
Autor(es): dc.contributorCatholic University of Brasília-
Autor(es): dc.creatorPiazza, Rodolfo Debone [UNESP]-
Autor(es): dc.creatorViali, Wesley Renato-
Autor(es): dc.creatorDos Santos, Caio Carvalho [UNESP]-
Autor(es): dc.creatorNunes, Eloiza S-
Autor(es): dc.creatorMarques, Rodrigo Fernando C [UNESP]-
Autor(es): dc.creatorMorais, Paulo C-
Autor(es): dc.creatorDa Silva, Sebastiaõ William-
Autor(es): dc.creatorCoaquira, José Antonio H-
Autor(es): dc.creatorJafelicci, Miguel [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:29:43Z-
Data de disponibilização: dc.date.available2022-02-22T00:29:43Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2019-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1088/2053-1591/ab6700-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/200189-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/200189-
Descrição: dc.descriptionSuperparamagnetic iron oxide nanoparticles (SPION) are of great interest for application in magnetic fluid hyperthermia (MFH) due to their heat generation capability in an external alternating magnetic field, besides biocompatibility, and surface properties. MFH has emerged as a promisor therapeutic approach for cancer treatment and is based in controlled heating tumor tissue through the accumulation of SPIONs within cancer cells. This work describes a new route for the preparation of folate-conjugated PEGylated SPIONs, which involves the attachment of such molecules at the surface through polycondensation reactions, without the need for coupling agents or prior modification on the species involved. The size of iron oxide cores obtained by transmission electron microscopy was about 12 nm. The conjugation of folate onto SPIONs was confirmed by FTIR spectroscopy. The folate conjugated nanoparticles were colloidal stable in PBS, presenting a hydrodynamic diameter of 109 ± 1 nm and PDI 0.148. The obtained folate-targeted PEGylated SPIONs showed superparamagnetic behavior with a saturation magnetization of 73.1 emu•g-1 at 300 K. Their specific absorption rate (SAR) ranged from 32.8 to 15.0 W g-1 in an alternating magnetic field of 10-16 kA m-1 and frequency of 420-203 kHz. The heat generated was sufficient to raise the sample temperature to the therapeutic range used in MFH establishing this system as promising candidates for use in MFH treatment.-
Descrição: dc.descriptionLaboratory of Magnetic Materials and Colloids Department of Physical Chemistry Institute of Chemistry Saõ Paulo State University (UNESP)-
Descrição: dc.descriptionInstituto Federal Goiano-
Descrição: dc.descriptionInstituto de Física Núcleo de Física Aplicada Universidade de Brasília-
Descrição: dc.descriptionGenomic Sciences and Biotechnology Catholic University of Brasília, Federal District-
Descrição: dc.descriptionLaboratory of Magnetic Materials and Colloids Department of Physical Chemistry Institute of Chemistry Saõ Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationMaterials Research Express-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectFolic acid-
Palavras-chave: dc.subjectHyperthermia-
Palavras-chave: dc.subjectPeglatyon-
Palavras-chave: dc.subjectSuperparamagnetic iron oxide-
Título: dc.titlePEGlatyon-SPION surface functionalization with folic acid for magnetic hyperthermia applications-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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