Postnatal exposure to finasteride causes different effects on the prostate of male and female gerbils

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorMaldarine, Juliana S.-
Autor(es): dc.creatorSanches, Bruno D. A.-
Autor(es): dc.creatorSantos, Vitória A. [UNESP]-
Autor(es): dc.creatorCabral, Ágata S. [UNESP]-
Autor(es): dc.creatorLima, Maria L. D. [UNESP]-
Autor(es): dc.creatorBedolo, Carolina M. [UNESP]-
Autor(es): dc.creatorCalmon, Marília F. [UNESP]-
Autor(es): dc.creatorRahal, Paula [UNESP]-
Autor(es): dc.creatorGóes, Rejane M. [UNESP]-
Autor(es): dc.creatorVilamaior, Patricia S. L. [UNESP]-
Autor(es): dc.creatorTaboga, Sebastião R. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:29:40Z-
Data de disponibilização: dc.date.available2022-02-22T00:29:40Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-06-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/cbin.11328-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/200174-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/200174-
Descrição: dc.descriptionThe development and maintenance of prostate function depend on a fine balance between oestrogen and androgen levels. Finasteride inhibits 5α-reductase, which is responsible for the conversion of testosterone into its most active form, dihydrotestosterone. Enzymes that metabolize these hormones have a highly relevant role in both the normal prostate metabolism and in the occurrence of pathological conditions. There are few studies on the impact of finasteride on male prostate development and fewer studies on the female prostate and possible intersexual differences. Therefore, we treated male and female gerbils from 7 to 14 days in postnatal life with a high dose of finasteride (500 μg/kg/day); the prostate complexes were then removed and submitted to immunohistochemistry, immunofluorescence and three-dimensional reconstruction. In addition, hormonal serum dosages were administered. Treatment with finasteride resulted in an increased thickness of the periductal smooth musculature in the prostate of both male and female gerbils, such as well as a reduction in the thickness of developing prostate alveoli in both sexes. In addition, intersexual differences were observed as increased epithelial proliferation and decreases in the number of developing alveoli in females. Together, the data indicate that postnatal exposure to finasteride causes greater changes in the female gerbil prostate than in the male.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biology State University of Campinas (UNICAMP), Bertrand RusseLl Av.-
Descrição: dc.descriptionLaboratory of Microscopy and Microanalysis Department of Biology São Paulo State University (UNESP), Cristóvão Colombo-
Descrição: dc.descriptionLaboratory of Genome Studies Department of Biology São Paulo State University (UNESP), Cristóvão Colombo-
Descrição: dc.descriptionLaboratory of Microscopy and Microanalysis Department of Biology São Paulo State University (UNESP), Cristóvão Colombo-
Descrição: dc.descriptionLaboratory of Genome Studies Department of Biology São Paulo State University (UNESP), Cristóvão Colombo-
Descrição: dc.descriptionFAPESP: 2013/15939-0-
Descrição: dc.descriptionFAPESP: 2016/16509-8-
Descrição: dc.descriptionCNPq: 305840/2015-0-
Descrição: dc.descriptionCNPq: 442630/2014-0-
Formato: dc.format1341-1352-
Idioma: dc.languageen-
Relação: dc.relationCell Biology International-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectandrogen receptor-
Palavras-chave: dc.subjectbranching morphogenesis-
Palavras-chave: dc.subjectdevelopmental exposure-
Palavras-chave: dc.subjectfemale prostate-
Palavras-chave: dc.subjectfinasteride-
Palavras-chave: dc.subjectgerbil-
Título: dc.titlePostnatal exposure to finasteride causes different effects on the prostate of male and female gerbils-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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