Loss of tumor-associated macrophages and vascular endothelial growth factor immunoexpression in solid mammary carcinoma in dogs

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorFranca University (UNIFRAN)-
Autor(es): dc.contributorScience and Technology of the South of Minas Gerais-
Autor(es): dc.creatorMatiz, Oscar Rodrigo Sierra [UNESP]-
Autor(es): dc.creatorSantilli, Juliana-
Autor(es): dc.creatorde Almeida, Maria Amélia Martins-
Autor(es): dc.creatorMagalhães, Larissa Fernandes-
Autor(es): dc.creatorMagalhães, Geórgia Modé-
Autor(es): dc.creatorAlves, Carlos Eduardo Fonseca [UNESP]-
Autor(es): dc.creatorde Nardi, Andrigo Barboza [UNESP]-
Autor(es): dc.creatorCalazans, Sabryna Gouveia [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:29:32Z-
Data de disponibilização: dc.date.available2022-02-22T00:29:32Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2019-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.29261/pakvetj/2019.105-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/200136-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/200136-
Descrição: dc.descriptionTumor-associated macrophages (TAM) are related to poor prognosis in canine mammary tumors (CMT). An association between TAM and sustained angiogenesis has been implicated with malignancy; however, comparison of the expression of TAM and vascular endothelial growth factor (VEGF) in different histologic types of CMT has not been completely studied. The objective of this study was to evaluate the immunostaining of TAM and VEGF in four different types of malignant CMT. Ninety-nine mammary carcinomas [tubular (29), tubulopapillary (22), mixed-type (28) and solid carcinoma (20)] were evaluated by immunohistochemical staining using MAC387 and VG-1 to detect TAM and VEGF immunoexpression, respectively. The total number of positive macrophages within the tumor was used for TAM immunolabeling and a score of four categories was used for VEGF immunolabeling. TAM immunoexpression was found to be statistically higher in tubular carcinomas than in solid carcinomas (P=0.0015). Differences between other types of carcinoma were not statistically significant. VEGF score was higher in tubular, papillary and mixed-type carcinomas than in solid carcinomas (P<0.0001). A positive relationship between the highest mean value of TAM and VEGF immunoexpression was also found (P=0.0015). TAM and VEGF expressions can be lost in more aggressive CMT, as in solid carcinoma. Furthermore, regardless of histologic type, higher numbers of TAM are associated with higher scores of VEGF, thus favoring the relationship between TAM and angiogenesis.-
Descrição: dc.descriptionClinic and Surgery Veterinary Department College of Agricultural and Veterinary Sciences São Paulo State University 'Júlio de Mesquita Filho' (UNESP), Via de Acesso Prof. Paulo Donato Castelane, S/N - Vila Industrial, Jaboticabal - SP-
Descrição: dc.descriptionCollege of Veterinary Medicine Franca University (UNIFRAN), Av. Dr. Armando de Sáles Oliveira, 201 - Parque Universitario-
Descrição: dc.descriptionPathology Department Federal Institute of Education Science and Technology of the South of Minas Gerais Campus of Muzambinho, Estrada de Muzambinho, km 35 - Bairro Morro Preto-
Descrição: dc.descriptionPathology Veterinary Department College of Veterinary and Zootechnical Medicine São Paulo State University 'Júlio de Mesquita Filho' (UNESP), Rua Prof. Doutor Walter Mauricio Correa, s/n.-
Descrição: dc.descriptionClinic and Surgery Veterinary Department College of Agricultural and Veterinary Sciences São Paulo State University 'Júlio de Mesquita Filho' (UNESP), Via de Acesso Prof. Paulo Donato Castelane, S/N - Vila Industrial, Jaboticabal - SP-
Descrição: dc.descriptionPathology Veterinary Department College of Veterinary and Zootechnical Medicine São Paulo State University 'Júlio de Mesquita Filho' (UNESP), Rua Prof. Doutor Walter Mauricio Correa, s/n.-
Formato: dc.format103-107-
Idioma: dc.languageen-
Relação: dc.relationPakistan Veterinary Journal-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectImmunohistochemistry-
Palavras-chave: dc.subjectMammary tumor-
Palavras-chave: dc.subjectTAM-
Palavras-chave: dc.subjectVEGF-
Título: dc.titleLoss of tumor-associated macrophages and vascular endothelial growth factor immunoexpression in solid mammary carcinoma in dogs-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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