Telomere Length and Telomerase Activity in Foetal Membranes from Term and Spontaneous Preterm Births

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUNOESTE-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorThe University of Texas Medical Branch at Galveston-
Autor(es): dc.contributorUniversidade Federal da Fronteira Sul-
Autor(es): dc.creatorColatto, Brunna Nepomuceno-
Autor(es): dc.creatorde Souza, Isabela Fiorentino-
Autor(es): dc.creatorSchinke, Laura Aparecida Antonio-
Autor(es): dc.creatorNoda-Nicolau, Nathalia Mayumi [UNESP]-
Autor(es): dc.creatorda Silva, Marcia Guimarães [UNESP]-
Autor(es): dc.creatorMorceli, Glilciane-
Autor(es): dc.creatorMenon, Ramkumar-
Autor(es): dc.creatorPolettini, Jossimara-
Data de aceite: dc.date.accessioned2022-02-22T00:29:21Z-
Data de disponibilização: dc.date.available2022-02-22T00:29:21Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2019-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s43032-019-00054-z-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/200088-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/200088-
Descrição: dc.descriptionThe reduction of telomere length, the protective cap structures of chromosomes, is one of the biomarkers of senescence (a mechanism of ageing), and ageing of foetal gestational tissues is associated with both term and preterm parturition. A mechanism regulating telomere length is the activity of telomerase, an enzyme that adds telomere fragments during DNA replication and cell division; however, its role in regulating telomere length is not well studied in gestational tissues. The objective of this study is to correlate telomere length and telomerase activity in foetal membranes from term and spontaneous preterm births. Foetal membrane samples were collected from pregnant women experiencing term labour (TL), term not in labour (TNL), preterm premature rupture of membranes (pPROM) and spontaneous preterm labour (PTL) with intact membranes (n = 20/group). Telomere length and telomerase activity were analyzed by relative quantification (T/S), real-time PCR and PCR-based fluorometric detection, respectively. Data were analyzed by ANOVA or the Kruskal-Wallis test. Demographic variables were not statistically different among the groups. Foetal membranes from the TL group showed telomere length reduction compared with those from the others (p < 0.0002). Telomerase activity did not change in foetal membranes irrespective of pregnancy outcome. Telomere shortening in foetal membranes is suggestive of senescence associated with triggering of labour at term; however, this is likely independent of telomerase activity, while prematurity may be associated with senescence, but due to other mechanisms than telomere length reduction in foetal membranes.-
Descrição: dc.descriptionUniversidade do Oeste Paulista UNOESTE-
Descrição: dc.descriptionDepartment of Pathology Botucatu Medical School Universidade Estadual Paulista UNESP-
Descrição: dc.descriptionDepartment of Obstetrics and Gynecology The University of Texas Medical Branch at Galveston-
Descrição: dc.descriptionUniversidade Federal da Fronteira Sul Campus Passo Fundo, Rua Capitão Araújo, 20, Centro-
Descrição: dc.descriptionDepartment of Pathology Botucatu Medical School Universidade Estadual Paulista UNESP-
Formato: dc.format411-417-
Idioma: dc.languageen-
Relação: dc.relationReproductive Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectGestational complications-
Palavras-chave: dc.subjectPregnancy-
Palavras-chave: dc.subjectSenescence-
Título: dc.titleTelomere Length and Telomerase Activity in Foetal Membranes from Term and Spontaneous Preterm Births-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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