Adenosine in the lateral hypothalamus/perifornical area does not participate on the CO2 chemoreflex

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorRodrigues, Laísa Taís Cabral [UNESP]-
Autor(es): dc.creatorSalata, Bruno [UNESP]-
Autor(es): dc.creatorHorta-Júnior, José de Anchieta C. [UNESP]-
Autor(es): dc.creatorGargaglioni, Luciane H. [UNESP]-
Autor(es): dc.creatorBarros Dias, Mirela [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:29:20Z-
Data de disponibilização: dc.date.available2022-02-22T00:29:20Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.resp.2020.103368-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/200081-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/200081-
Descrição: dc.descriptionThe Lateral Hypothalamus/Perifornical Area (LH/PFA) has been shown to be involved with the hypercapnic ventilatory response, in a state-dependent manner. We have demonstrated that purinergic signaling through ATP in the LH/PFA has an excitatory effect in ventilatory response to CO2 in awake rats in the dark phase of the diurnal cycle, but it is unknown whether the ATP metabolite adenosine, acting in the LH/PFA, modulates the ventilatory responses to hypercapnia. Here, we studied the effects of the microdialysis of adenosine (A1/A2 adenosine receptors agonist; 17 mM) and an A1 receptor antagonist (DPCPX; 0.1 mM) into the LH/PFA of conscious rats on ventilation in room air and in 7% CO2 during the light and the dark phases of the diurnal cycle. The microdialysis of adenosine and DPCPX caused no change in the CO2 ventilatory responses of rats during wakefulness or NREM sleep in either the dark or light period. Our data suggest that adenosine in the LH/PFA does not contribute to the hypercapnic ventilatory response in conscious rats.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Physiology Institute of Biosciences Sao Paulo State University-UNESP-
Descrição: dc.descriptionDepartment of Anatomy Institute of Biosciences Sao Paulo State University-UNESP-
Descrição: dc.descriptionDepartment of Animal Morphology and Physiology Sao Paulo State University-FCAV-
Descrição: dc.descriptionDepartment of Physiology Institute of Biosciences Sao Paulo State University-UNESP-
Descrição: dc.descriptionDepartment of Anatomy Institute of Biosciences Sao Paulo State University-UNESP-
Descrição: dc.descriptionDepartment of Animal Morphology and Physiology Sao Paulo State University-FCAV-
Descrição: dc.descriptionFAPESP: 2017/02181-3-
Idioma: dc.languageen-
Relação: dc.relationRespiratory Physiology and Neurobiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAdenosine-
Palavras-chave: dc.subjectCentral chemoreception-
Palavras-chave: dc.subjectDPCPX-
Palavras-chave: dc.subjectHypercapnia-
Palavras-chave: dc.subjectHypothalamus-
Título: dc.titleAdenosine in the lateral hypothalamus/perifornical area does not participate on the CO2 chemoreflex-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.