Cyclosporine A impairs bone repair in critical defects filled with different osteoconductive bone substitutes

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade Federal de Uberlândia (UFU)-
Autor(es): dc.contributorSection of Oral Radiology-
Autor(es): dc.contributorMalmo University-
Autor(es): dc.creatorGonçalves, Fernanda Castanheira [UNESP]-
Autor(es): dc.creatorde Oliveira, Guilherme José Pimentel Lopes-
Autor(es): dc.creatorScardueli, Cassio Rocha [UNESP]-
Autor(es): dc.creatorSpin-Neto, Rubens-
Autor(es): dc.creatorStavropoulos, Andreas-
Autor(es): dc.creatorMarcantonio, Rosemary Adriana Chiérici [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:29:16Z-
Data de disponibilização: dc.date.available2022-02-22T00:29:16Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2019-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/1807-3107BOR-2020.VOL34.0007-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/200063-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/200063-
Descrição: dc.descriptionThe aim of this study was to assess the influence of cyclosporine administration on the repair of critical-sized calvaria defects (CSDs) in rat calvaria filled with diverse biomaterials. Sixty animals were divided into two groups: the control (CTR) group (saline solution) and the cyclosporine (CCP) group (cyclosporine, 10 mg/kg/day). These medications were administered daily by gavage, beginning 15 days before the surgical procedure and lasting until the day the animals were euthanized. A CSD (5 mm O) was made in the calvaria of each animal, which was allocated to one of 3 subgroups, according to the biomaterial used to fill the defect: coagulum (COA), deproteinized bovine bone (DBB), or biphasic calcium phosphate ceramics of hydroxyapatite and β-phosphate tricalcium (HA/TCP). Euthanasia of the animals was performed 15 and 60 days after the surgical procedure (n = 5 animals/period/subgroup). Bone repair (formation) assessment was performed through microtomography and histometry, while the analyses of the expression of the BMP2, Osteocalcin, and TGFβ1 proteins were performed using immunohistochemistry. The CSDs not filled with biomaterials demonstrated lower bone formation in the CCP group. At 15 days, less bone formation was observed in the CSDs filled with DBB, a smaller volume of mineralized tissue was observed in the CSDs filled with HA/TCP, and the expression levels of BMP2 and osteocalcin were lower in the CCP group compared to the CTR group. The use of cyclosporine impaired bone repair in CSD, and this effect can be partially explained by the suppression of BMP2 and osteocalcin expression.-
Descrição: dc.descriptionUniversidade Estadual de São Paulo-Unesp School of Dentistry Araraquara Department of Diagnosis and Surgery-
Descrição: dc.descriptionUniversidade Federal de Uberlândia-UFU Dental School Department of Periodontology-
Descrição: dc.descriptionAarhus University Department of Dentistry and Oral Health Section of Oral Radiology-
Descrição: dc.descriptionMalmo University Department of Community Dentistry and Periodontology-
Descrição: dc.descriptionUniversidade Estadual de São Paulo-Unesp School of Dentistry Araraquara Department of Diagnosis and Surgery-
Idioma: dc.languageen-
Relação: dc.relationBrazilian Oral Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBone regeneration-
Palavras-chave: dc.subjectBone substitutes-
Palavras-chave: dc.subjectImmunosuppression-
Título: dc.titleCyclosporine A impairs bone repair in critical defects filled with different osteoconductive bone substitutes-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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