Resistin Is Increased in Periodontal Cells and Tissues: In Vitro and in Vivo Studies

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorJohannes Gutenberg University-
Autor(es): dc.contributorUniversity of Bonn-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversity of Bern-
Autor(es): dc.creatorNogueira, Andressa V. B.-
Autor(es): dc.creatorNokhbehsaim, Marjan-
Autor(es): dc.creatorTekin, Sema-
Autor(es): dc.creatorDe Molon, Rafael S. [UNESP]-
Autor(es): dc.creatorSpolidorio, Luis C. [UNESP]-
Autor(es): dc.creatorMemmert, Svenja-
Autor(es): dc.creatorDamanaki, Anna-
Autor(es): dc.creatorJäger, Andreas-
Autor(es): dc.creatorEick, Sigrun-
Autor(es): dc.creatorDeschner, James-
Autor(es): dc.creatorCirelli, Joni A. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:29:13Z-
Data de disponibilização: dc.date.available2022-02-22T00:29:13Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2019-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1155/2020/9817095-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/200047-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/200047-
Descrição: dc.descriptionResistin, a proinflammatory adipokine, is elevated in many inflammatory diseases. However, little is known about its performance in periodontitis. The present study is aimed at evaluating resistin expression and synthesis in periodontal cells and tissues under inflammatory/microbial stress in addition to its effects on the periodontium. In vivo, 24 male rats were randomly divided into two groups: control and ligature-induced periodontal disease. After 6 and 12 days, animals were sacrificed to analyze gene expression of adipokines, bone loss, inflammation, and resistin synthesis. In vitro, human periodontal ligament (PDL) fibroblasts were used to evaluate the expression of resistin after inflammatory stimuli. In addition, PDL fibroblasts were exposed to resistin to evaluate its role on soft and hard tissue metabolism markers. The periodontitis group demonstrated significant bone loss, an increase in the number of inflammatory cells and vascular structures, an increase in resistin expression and synthesis, and a decrease in the expression of adiponectin, leptin, and its functional receptor. PDL fibroblasts showed a significant increase in resistin expression and synthesis in response to the inflammatory stimulus by IL-1β. Resistin induced an increase in cytokine expression and a decrease in the regulation of some hard tissue and matrix formation genes in PDL fibroblasts. These data indicate that resistin is produced by periodontal cells and tissues, and this effect is enhanced by inflammatory stimuli. Moreover, resistin seems to interfere with soft and hard tissue metabolism during periodontitis by reducing markers related to matrix formation and bone tissue.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Periodontology and Operative Dentistry University Medical Center Johannes Gutenberg University-
Descrição: dc.descriptionSection of Experimental Dento-Maxillo-Facial Medicine Center of Dento-Maxillo-Facial Medicine University of Bonn-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery School of Dentistry at Araraquara São Paulo State University-UNESP-
Descrição: dc.descriptionDepartment of Physiology and Pathology School of Dentistry at Araraquara São Paulo State University-UNESP-
Descrição: dc.descriptionDepartment of Orthodontics Center of Dento-Maxillo-Facial Medicine University of Bonn-
Descrição: dc.descriptionDepartment of Periodontology Laboratory of Oral Microbiology University of Bern-
Descrição: dc.descriptionFormerly Clinical Research Unit 208 University of Bonn-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery School of Dentistry at Araraquara São Paulo State University-UNESP-
Descrição: dc.descriptionDepartment of Physiology and Pathology School of Dentistry at Araraquara São Paulo State University-UNESP-
Descrição: dc.descriptionFAPESP: 2010/07771-4-
Descrição: dc.descriptionFAPESP: 2011/13752-5-
Descrição: dc.descriptionFAPESP: 2014/20715-7-
Descrição: dc.descriptionFAPESP: 2017/07137-2-
Idioma: dc.languageen-
Relação: dc.relationMediators of Inflammation-
???dc.source???: dc.sourceScopus-
Título: dc.titleResistin Is Increased in Periodontal Cells and Tissues: In Vitro and in Vivo Studies-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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