Food safety evaluation for the use of albendazole in fish: residual depletion profile and withdrawal period estimation

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorQueen’s University Belfast-
Autor(es): dc.creatorPortela, Ana Carolina Vellosa-
Autor(es): dc.creatorSilveira, Juliana Grell Fernandes-
Autor(es): dc.creatorDamaceno, Marina Alves-
Autor(es): dc.creatorda Silva, Agnaldo Fernando Baldo-
Autor(es): dc.creatorde Jesus, Raphael Barbetta [UNESP]-
Autor(es): dc.creatorPilarski, Fabiana [UNESP]-
Autor(es): dc.creatorGadaj, Anna-
Autor(es): dc.creatorMooney, Mark H.-
Autor(es): dc.creatorPaschoal, Jonas Augusto Rizzato-
Data de aceite: dc.date.accessioned2022-02-22T00:29:12Z-
Data de disponibilização: dc.date.available2022-02-22T00:29:12Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-04-02-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/19440049.2020.1719285-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/200040-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/200040-
Descrição: dc.descriptionDue to the lack of drugs regulated for aquaculture, we have evaluated the use of albendazole (ABZ)–a potential drug to be regulated for fish–under food safety perspectives assessing the depletion profile of ABZ and its main metabolites (albendazole sulphoxide–ABZSO, albendazole sulphone–ABZSO2 and albendazole amino sulphone–ABZ-2-NH2SO2) in fish fillets (muscle and skin) after single dose oral administration of 10 mg ABZ kg-1 body weight. For the drug administration, a suitable procedure for ABZ incorporation into fish feed was employed, obtaining good homogeneity of ABZ concentration among feed pellets (CV<4.1%) and low drug leaching when medicated feed remained in the water for up to 60 min (<2.7%). After medication, fish were euthanised at 8, 12, 24, 48, 72, 96 and 120 h and fillets collected. Depletion studies in various fish species (patinga and tilapia) were conducted simultaneously, under water temperature at 30.4 ± 0.3 °C and pH 6.8 ± 0.1. The highest concentrations for the sum of residues (ABZ, ABZSO, ABZSO2 and ABZ-2-NH2SO2) in fish fillet were 1210 ng g-1 in patinga and 637 ng g−1 in tilapia. Under the employed rearing conditions, the obtained results did not indicate a requirement for a minimum withdrawal period to be proposed for tilapia considering the maximum residue limit of 100 µg g−1, since the determined residual concentration was <LOQ (10 ng g−1) from 24 h post medication treatment. For patinga, the estimated minimum withdrawal period was 3 days. With the well-recognised demands for new alternative veterinary drugs for aquaculture use by fish farmers, this study offers important evidence for consideration of ABZ use in tilapia and patinga taking into account food safety issues.-
Descrição: dc.descriptionFaculdade de Ciências Farmacêuticas de Ribeirão Preto Departamento de Física e Química Universidade de São Paulo-
Descrição: dc.descriptionCentro de Aquicultura da Unesp Universidade Estadual Paulista (Unesp)-
Descrição: dc.descriptionInstitute for Global Food Security School of Biological Sciences Queen’s University Belfast-
Descrição: dc.descriptionCentro de Aquicultura da Unesp Universidade Estadual Paulista (Unesp)-
Formato: dc.format596-606-
Idioma: dc.languageen-
Relação: dc.relationFood Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectalbendazole-
Palavras-chave: dc.subjectAquaculture-
Palavras-chave: dc.subjectfeed medication-
Palavras-chave: dc.subjectLC-MS/MS-
Palavras-chave: dc.subjectpatinga-
Palavras-chave: dc.subjecttilapia-
Palavras-chave: dc.subjectwithdrawal period-
Título: dc.titleFood safety evaluation for the use of albendazole in fish: residual depletion profile and withdrawal period estimation-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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