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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.contributor | Brigham and Women's Hospital | - |
Autor(es): dc.contributor | Harvard Medical School | - |
Autor(es): dc.creator | Maestá, Izildinha [UNESP] | - |
Autor(es): dc.creator | Nitecki, Roni | - |
Autor(es): dc.creator | Desmarais, Cecilia Canedo Freitas [UNESP] | - |
Autor(es): dc.creator | Horowitz, Neil S. | - |
Autor(es): dc.creator | Goldstein, Donald P. | - |
Autor(es): dc.creator | Elias, Kevin M. | - |
Autor(es): dc.creator | Berkowitz, Ross S. | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:29:08Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:29:08Z | - |
Data de envio: dc.date.issued | 2020-12-11 | - |
Data de envio: dc.date.issued | 2020-12-11 | - |
Data de envio: dc.date.issued | 2020-05-01 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1016/j.ygyno.2020.02.001 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/200030 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/200030 | - |
Descrição: dc.description | Objectives: The purpose of this study was to evaluate both the outcomes and toxicity of second-line actinomycin D (ActD) chemotherapy in methotrexate (MTX) - resistant low-risk postmolar gestational trophoblastic neoplasia (GTN) with 5-day ActD versus pulsed ActD. Methods: This retrospective cohort study included patients with MTX-resistant low-risk postmolar GTN from 1974 to 2016. Second-line chemotherapy consisted of 5-day ActD (10–12 μg/kg per day for 5 days every 14 days) or biweekly ActD (1.25 mg/m2 every 2 weeks). Data on patient characteristics, disease presentation, treatment outcome, and toxicity were collected. Results: Sixty-eight MTX-resistant patients receiving ActD as second-line chemotherapy were identified (5-day ActD, 53 patients; pulsed ActD, 15 patients). No significant differences were observed in patient/disease characteristics and sustained remission (overall rate 72%) between second-line ActD regimens. Time to hCG remission was significantly faster (median 21 vs 47 days, p = .04) and required fewer treatment cycles (median 1 vs 2, p < .001) with 5-day ActD. Thrombocytopenia was only observed with 5-day ActD (64.6 vs 0%, p < .001). The frequency (60.4 vs 16.7%, p = .009) and severity (grade 3: 37.9 vs 0%, p = .045) of oral mucositis was significantly higher with 5-day ActD. Grade 2 alopecia was significantly more frequent (70.6 vs 16.7%, p = .02) with 5-day ActD. Conclusions: While 5-day ActD and pulsed ActD achieve comparable remission rates, due to its reduced toxicity, ease of administration, and patient convenience, pulsed ActD should be the treatment of choice for MTX-resistant postmolar low-risk GTN. | - |
Descrição: dc.description | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | - |
Descrição: dc.description | Botucatu Trophoblastic Disease Center Botucatu Medical School Hospital Department of Gynecology and Obstetrics UNESP—Sao Paulo State University | - |
Descrição: dc.description | Postgraduate Program in Tocogynecology of Botucatu Medical School UNESP—São Paulo State University | - |
Descrição: dc.description | Department of Obstetrics and Gynecology Brigham and Women's Hospital | - |
Descrição: dc.description | New England Trophoblastic Disease Center Division of Gynecologic Oncology Department of Obstetrics Gynecology and Reproductive Biology Brigham and Women's Hospital | - |
Descrição: dc.description | Harvard Medical School | - |
Descrição: dc.description | Botucatu Trophoblastic Disease Center Botucatu Medical School Hospital Department of Gynecology and Obstetrics UNESP—Sao Paulo State University | - |
Descrição: dc.description | Postgraduate Program in Tocogynecology of Botucatu Medical School UNESP—São Paulo State University | - |
Formato: dc.format | 372-378 | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Gynecologic Oncology | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | Actinomycin D | - |
Palavras-chave: dc.subject | Effectiveness | - |
Palavras-chave: dc.subject | Low-risk gestational trophoblastic neoplasia | - |
Palavras-chave: dc.subject | Second-line chemotherapy | - |
Palavras-chave: dc.subject | Toxicity | - |
Título: dc.title | Effectiveness and toxicity of second-line actinomycin D in patients with methotrexate-resistant postmolar low-risk gestational trophoblastic neoplasia | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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