Physical resistance training-induced changes in lipids metabolism pathways and apoptosis in prostate

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversity of Western São Paulo-UNOESTE-
Autor(es): dc.contributorUniversity of Guelph-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.creatorTeixeira, Giovana Rampazzo [UNESP]-
Autor(es): dc.creatorMendes, Leonardo Oliveira-
Autor(es): dc.creatorVeras, Allice Santos Cruz [UNESP]-
Autor(es): dc.creatorThorpe, Hayley Hope Allyssa-
Autor(es): dc.creatorFávaro, Wagner José-
Autor(es): dc.creatorDe Almeida Chuffa, Luiz Gustavo [UNESP]-
Autor(es): dc.creatorPinheiro, Patrícia Fernanda Felipe [UNESP]-
Autor(es): dc.creatorMartinez, Francisco Eduardo [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:29:06Z-
Data de disponibilização: dc.date.available2022-02-22T00:29:06Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-01-28-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1186/s12944-020-1195-0-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/200015-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/200015-
Descrição: dc.descriptionBackground: Altered lipid metabolism is an important characteristic of neoplastic cells, with androgens and growth factors being major regulatory agents of the lipid metabolism process. We investigated the effect of physical resistance training on lipid metabolism and apoptosis in the adult Wistar rat prostate. Methods: Two experimental groups represented sedentary and physical resistance training. Three days per week for 13 weeks, rats performed jumps in water carrying a weight load strapped to their chests as part of a physical resistance exercise protocol. Two days after the last training session, rats were anesthetized and sacrificed for blood and prostate analysis. Results: Physical exercise improved feeding efficiency, decreased weight gain, regulated the serum-lipid profile, and modulated insulin-like growth factor-1 (IGF-1) and free testosterone concentration. Furthermore, upregulation of cluster of differentiation 36 (CD36), sterol regulatory element binding protein-1 (SREBP-1), sterol regulatory element-binding protein cleavage-activating protein (SCAP), and reduced lysosome membrane protein (LIMPII) expression were also observed in the blood and prostates of trained rats. Consistent with these results, caspase-3 expression was upregulating and the BCL-2/Bax index ratio was decreased in trained rats relative to sedentary animals. Conclusions: In this work, physical resistance training can alter lipid metabolism and increase markers of apoptosis in the prostate, suggesting physical resistance training as a potential novel therapeutic strategy for treating prostate cancer.-
Descrição: dc.descriptionDepartment of Physiotherapy School of Technology and Sciences UNESP Campus of Presidente Prudente-
Descrição: dc.descriptionPostgraduate Program in Movement Sciences Sao Paulo State University-UNESP-
Descrição: dc.descriptionMulticenter Graduate Program in Physiological Sciences SBFis São Paulo State University (UNESP)-
Descrição: dc.descriptionPostgraduate Program in Animal Science Postgraduate Program in Health Sciences University of Western São Paulo-UNOESTE-
Descrição: dc.descriptionDepartment of Biomedical Sciences Ontario Veterinary College University of Guelph-
Descrição: dc.descriptionDepartment of Structural and Functional Biology State University of Campinas - UNICAMP Institute of Biology-
Descrição: dc.descriptionDepartment of Anatomy São Paulo State University UNESP Institute of Biosciences-
Descrição: dc.descriptionDepartment of Physiotherapy School of Technology and Sciences UNESP Campus of Presidente Prudente-
Descrição: dc.descriptionPostgraduate Program in Movement Sciences Sao Paulo State University-UNESP-
Descrição: dc.descriptionMulticenter Graduate Program in Physiological Sciences SBFis São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Anatomy São Paulo State University UNESP Institute of Biosciences-
Idioma: dc.languageen-
Relação: dc.relationLipids in Health and Disease-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectApoptosis-
Palavras-chave: dc.subjectCD36-
Palavras-chave: dc.subjectPhysical exercise-
Palavras-chave: dc.subjectSCAP-
Palavras-chave: dc.subjectSREBP-1-
Título: dc.titlePhysical resistance training-induced changes in lipids metabolism pathways and apoptosis in prostate-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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