High concentrations of waste anesthetic gases induce genetic damage and inflammation in physicians exposed for three years: A cross-sectional study

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorTufts University-
Autor(es): dc.creatorBraz, Mariana G. [UNESP]-
Autor(es): dc.creatorCarvalho, Lorena I. M. [UNESP]-
Autor(es): dc.creatorChen, Chung-Yen O.-
Autor(es): dc.creatorBlumberg, Jeffrey B.-
Autor(es): dc.creatorSouza, Kátina M. [UNESP]-
Autor(es): dc.creatorArruda, Nayara M. [UNESP]-
Autor(es): dc.creatorFilho, Daniel A. A. [UNESP]-
Autor(es): dc.creatorResende, Ludimila O. [UNESP]-
Autor(es): dc.creatorFaria, Renata T. B. G. [UNESP]-
Autor(es): dc.creatorCanário, Clara d'A. [UNESP]-
Autor(es): dc.creatorde Carvalho, Lídia R. [UNESP]-
Autor(es): dc.creatorCorrêa, Camila R. [UNESP]-
Autor(es): dc.creatorBraz, José Reinaldo C. [UNESP]-
Autor(es): dc.creatorBraz, Leandro G. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:29:04Z-
Data de disponibilização: dc.date.available2022-02-22T00:29:04Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/ina.12643-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/200006-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/200006-
Descrição: dc.descriptionThis cross-sectional study analyzed the impact of occupational waste anesthetic gases on genetic material, oxidative stress, and inflammation status in young physicians exposed to inhalational anesthetics at the end of their medical residency. Concentrations of waste anesthetic gases were measured in the operating rooms to assess anesthetic pollution. The exposed group comprised individuals occupationally exposed to inhalational anesthetics, while the control group comprised individuals without anesthetic exposure. We quantified DNA damage; genetic instability (micronucleus-MN); protein, lipid, and DNA oxidation; antioxidant activities; and proinflammatory cytokine levels. Trace concentrations of anesthetics (isoflurane: 5.3 ± 2.5 ppm, sevoflurane: 9.7 ± 5.9 ppm, and nitrous oxide: 180 ± 150 ppm) were above international recommended thresholds. Basal DNA damage and IL-17A were significantly higher in the exposed group [27 ± 20 a.u. and 20.7(19.1;31.8) pg/mL, respectively] compared to the control group [17 ± 11 a.u. and 19.0(18.9;19.5) pg/mL, respectively], and MN frequency was slightly increased in the exposed physicians (2.3-fold). No significant difference was observed regarding oxidative stress biomarkers. The findings highlight the genetic and inflammatory risks in young physicians exposed to inhalational agents in operating rooms lacking adequate scavenging systems. This potential health hazard can accompany these subjects throughout their professional lives and reinforces the need to reduce ambient air pollution and consequently, occupational exposure.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionAgricultural Research Service-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionGENOTOX Laboratory - UNIPEX Department of Anesthesiology Medical School São Paulo State University - UNESP-
Descrição: dc.descriptionAntioxidants Research Laboratory Jean Mayer USDA Human Nutrition Research Center on Aging Tufts University-
Descrição: dc.descriptionDepartment of Bioestatistics Institute of Biosciences São Paulo State University - UNESP-
Descrição: dc.descriptionDepartment of Pathology Medical School São Paulo State University - UNESP-
Descrição: dc.descriptionGENOTOX Laboratory - UNIPEX Department of Anesthesiology Medical School São Paulo State University - UNESP-
Descrição: dc.descriptionDepartment of Bioestatistics Institute of Biosciences São Paulo State University - UNESP-
Descrição: dc.descriptionDepartment of Pathology Medical School São Paulo State University - UNESP-
Descrição: dc.descriptionCAPES: 14527-13-8-
Descrição: dc.descriptionCNPq: 164242/2014-7-
Descrição: dc.descriptionAgricultural Research Service: 1950-51000-087-
Descrição: dc.descriptionFAPESP: 2013/12120-0-
Descrição: dc.descriptionFAPESP: 2013/18075-7-
Descrição: dc.descriptionFAPESP: 2013/21130-0-
Descrição: dc.descriptionFAPESP: 2014/08661-9-
Descrição: dc.descriptionFAPESP: 2015/06420-7-
Descrição: dc.descriptionCNPq: 472453/2013-0-
Formato: dc.format512-520-
Idioma: dc.languageen-
Relação: dc.relationIndoor Air-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectgenomic instability-
Palavras-chave: dc.subjectindoor air pollution-
Palavras-chave: dc.subjectinflammation-
Palavras-chave: dc.subjectinhalation anesthetics-
Palavras-chave: dc.subjectoxidative stress-
Palavras-chave: dc.subjectwork environment-
Título: dc.titleHigh concentrations of waste anesthetic gases induce genetic damage and inflammation in physicians exposed for three years: A cross-sectional study-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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