Dynamics of plasma micronutrient concentrations and their correlation with serum proteins and thyroid hormones in patients with paracoccidioidomycosis

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorFederal University of Mato Grosso Do sul-
Autor(es): dc.contributorUniversidade Estadual de Maringá (UEM)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorDe Oliveira Custódio, Jeniffer Michelline-
Autor(es): dc.creatorEnokida, Iasmim Mayumi-
Autor(es): dc.creatorGonçalves, Daniel Araujo-
Autor(es): dc.creatorDe Oliveira, Sandra Maria Do Valle Leone-
Autor(es): dc.creatorVenturini, James-
Autor(es): dc.creatorCarvalho, Lidia Raquel [UNESP]-
Autor(es): dc.creatorMendes, Rinaldo Poncio [UNESP]-
Autor(es): dc.creatorPaniago, Anamaria Mello Miranda-
Data de aceite: dc.date.accessioned2022-02-22T00:28:40Z-
Data de disponibilização: dc.date.available2022-02-22T00:28:40Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2019-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0226609-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/199882-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/199882-
Descrição: dc.descriptionMinerals, such as zinc, copper, and iron are reported to play roles in chronic infectious diseases; however, their role in paracoccidioidomycosis (PCM) remains unknown. This study aimed to examine the micronutrient dynamics and their correlation with serum proteins and thyroid hormones in patients with PCM. In 14 patients with PCM and 10 healthy subjects, we evaluated the body mass index (BMI) along with serum levels of hemoglobin, iron, ferritin, zinc, copper, magnesium, albumin, globulin, thyroid stimulating hormone (TSH), thyroxine (free T4), and triiodothyronine (T3). Evaluations were conducted at the first appointment, before treatment, and at the end of the first, second, fourth, and sixth month of PCM treatment. The control group was only evaluated once. We observed that before treatment, patients with PCM, had higher levels of copper and lower level of iron than those of the control group. After one month of treatment, the iron levels increased, whereas the levels of copper after six months of treatment. Reduction in inflammatory activity, indicated by the normalization of C-reactive protein, ferritin, albumin, and globulin levels, was observed during treatment. However, no correlation was observed between the serum levels of minerals and inflammatory activity or thyroid function in this study. In conclusion, our results showed higher serum copper levels in control group compared to those in pretreatment patients; the clinical importance of this observation should be investigated in further studies. After treatment, serum copper levels showed a tendency to decrease. In addition, serum iron levels were decreased at the stage of active disease, and were increased after treatment. Thus, serum iron levels can be used as a better biomarker for treatment control.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionPostgraduate Course in Health and Development of the Central West Region Federal University of Mato Grosso Do sul-
Descrição: dc.descriptionScientific Initiation CNPq Faculty of Medicine - FAMED Federal University of Mato Grosso Do sul-
Descrição: dc.descriptionDepartment of Chemistry Minas Gerais State University - UEMG-
Descrição: dc.descriptionFaculty of Medicine- FAMED Center for Biological and Health Sciences- CCBS Federal University of Mato Grosso Do sul-
Descrição: dc.descriptionDepartment of Biostatistics Institute of Biosciences State University Paulista júlio de Mesquita Filho -UNESP-
Descrição: dc.descriptionDepartment of Tropical Diseases Botucatu Medical School Universidade Estadual Paulista (UNESP)-
Descrição: dc.descriptionDepartment of Biostatistics Institute of Biosciences State University Paulista júlio de Mesquita Filho -UNESP-
Descrição: dc.descriptionDepartment of Tropical Diseases Botucatu Medical School Universidade Estadual Paulista (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationPLoS ONE-
???dc.source???: dc.sourceScopus-
Título: dc.titleDynamics of plasma micronutrient concentrations and their correlation with serum proteins and thyroid hormones in patients with paracoccidioidomycosis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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