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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | University of North Carolina at Chapel Hill | - |
Autor(es): dc.contributor | The University of North Carolina at Chapel Hill | - |
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.contributor | Geisinger Health Weis Center for Research | - |
Autor(es): dc.creator | Barros, Silvana P. | - |
Autor(es): dc.creator | Fahimipour, Farahnaz | - |
Autor(es): dc.creator | Tarran, Robert | - |
Autor(es): dc.creator | Kim, Steven | - |
Autor(es): dc.creator | Scarel-Caminaga, Raquel Mantuaneli [UNESP] | - |
Autor(es): dc.creator | Justice, Anne | - |
Autor(es): dc.creator | North, Kari | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:28:25Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:28:25Z | - |
Data de envio: dc.date.issued | 2020-12-11 | - |
Data de envio: dc.date.issued | 2020-12-11 | - |
Data de envio: dc.date.issued | 2020-01-31 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1111/prd.12322 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/199824 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/199824 | - |
Descrição: dc.description | Periodontitis is a chronic multifactorial inflammatory disease associated with microbial dysbiosis and characterized by progressive destruction of the periodontal tissues. Such chronic infectious inflammatory disease is recognized as a major public health problem worldwide with measurable impact in systemic health. It has become evident that the periodontal disease phenotypes are not only determined by the microbiome effect, but the extent of the tissue response is also driven by the host genome and epigenome patterns responding to various environmental exposures. More recently there is mounting evidence indicating that epigenetic reprogramming in response to combined intrinsic and environmental exposures, might be particularly relevant due its plasticity and potential application towards precision health. The complex epigenetic crosstalk is reflected in the prognosis and progress of periodontal diseases and may also lead to a favorable landscape for cancer development. This review discusses epigenomics modifications focusing on the role of DNA methylation and pathways linking microbial infection and inflammatory pathways, which are also associated with carcinogenesis. There is a more clear vision whereas 'omics' technologies applied to unveil relevant epigenetic factors could play a significant role in the treatment of periodontal disease in a personalized mode, evidencing that public health approach should coexist with precision individualized treatment. | - |
Descrição: dc.description | Department of Periodontology University of North Carolina at Chapel Hill | - |
Descrição: dc.description | Department of Cell Biology & Physiology Marsico Lung Institute The University of North Carolina at Chapel Hill | - |
Descrição: dc.description | Department of Morphology School of Dentistry at Araraquara UNESP- São Paulo State University | - |
Descrição: dc.description | Biomedical and Translational Informatics Geisinger Health Weis Center for Research | - |
Descrição: dc.description | Department of Epidemiology Gillings School of Global Public Health University of North Carolina at Chapel Hill | - |
Descrição: dc.description | Department of Morphology School of Dentistry at Araraquara UNESP- São Paulo State University | - |
Formato: dc.format | 157-172 | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Periodontology 2000 | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | epigenetic | - |
Palavras-chave: dc.subject | inflammation | - |
Palavras-chave: dc.subject | oncogenesis | - |
Palavras-chave: dc.subject | periodontal disease | - |
Título: dc.title | Epigenetic reprogramming in periodontal disease: Dynamic crosstalk with potential impact in oncogenesis | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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