Genotoxic permanent hair dye precursors p-aminophenol and p-toluenediamine electrochemical oxidation mechanisms and evaluation in biological fluids

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversity of Coimbra-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorde Souza, João Carlos [UNESP]-
Autor(es): dc.creatorZanoni, Maria Valnice Boldrin [UNESP]-
Autor(es): dc.creatorOliveira-Brett, Ana Maria-
Data de aceite: dc.date.accessioned2022-02-22T00:28:19Z-
Data de disponibilização: dc.date.available2022-02-22T00:28:19Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-01-14-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jelechem.2019.113509-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/199788-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/199788-
Descrição: dc.descriptionThe p-toluenediamine (PTD) and p-aminophenol (PAP), genotoxic precursor agents widely used in permanent hair dyeing formulations, electrochemical mechanisms and evaluation in biological fluids, at a glassy carbon electrode, in a wide pH range, by cyclic, differential pulse, and square wave voltammetry, were investigated. The oxidation of both PTD and PAP is reversible. The PTD two electrons and two protons transfer diffusion-controlled reaction occurs at the molecule nitrogen atoms in the amine groups. Also PAP oxidation is a two electrons and two protons transfer diffusion-controlled reactions, and occur at the nitrogen and oxygen atoms of the molecule amine and hydroxyl groups. An electrochemical oxidation mechanism for PTD and PAP is proposed. The PTD and PAP diffusion coefficients, DPTD = 1.57 × 10−5 cm2 s−1 for PTD, and DPAP = 1.03 × 10−5 cm2 s−1 for PAP, were determined. The electrochemical quantification in 0.10–1.00 μM concentration range showed a detection limit of 0.12 μM for PTD and 0.17 μM PAP. A new electroanalytical method for the determination of PTD and PAP in fetal bovine serum biological fluid, and in artificial urine samples, using differential pulse voltammetry, was also developed.-
Descrição: dc.descriptionPrograma Operacional Temático Factores de Competitividade-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionFundação para a Ciência e a Tecnologia-
Descrição: dc.descriptionDepartment of Chemistry Faculty of Sciences and Technology University of Coimbra-
Descrição: dc.descriptionInstitute of Chemistry Department of Analytical Chemistry National Institute of Alternative Technologies for Detection Toxicological Assessment and Removal of Micropollutants and Radioactive (INCT-DATREM) São Paulo State University (UNESP)-
Descrição: dc.descriptionInstitute of Chemistry Department of Analytical Chemistry National Institute of Alternative Technologies for Detection Toxicological Assessment and Removal of Micropollutants and Radioactive (INCT-DATREM) São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationJournal of Electroanalytical Chemistry-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectElectrochemical oxidation-
Palavras-chave: dc.subjectGenotoxic precursors-
Palavras-chave: dc.subjectGlassy carbon electrode-
Palavras-chave: dc.subjectHair dyes-
Palavras-chave: dc.subjectP-aminophenol-
Palavras-chave: dc.subjectP-toluenediamine-
Título: dc.titleGenotoxic permanent hair dye precursors p-aminophenol and p-toluenediamine electrochemical oxidation mechanisms and evaluation in biological fluids-
Tipo de arquivo: dc.typelivro digital-
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