Insights into the impact of cross-linking processes on physicochemical characteristics and mucoadhesive potential of gellan gum/retrograded starch microparticles as a platform for colonic drug release

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorde Oliveira Cardoso, Valéria Maria [UNESP]-
Autor(es): dc.creatorEvangelista, Raul Cesar [UNESP]-
Autor(es): dc.creatorDaflon Gremião, Maria Palmira [UNESP]-
Autor(es): dc.creatorStringhetti Ferreira Cury, Beatriz [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:28:18Z-
Data de disponibilização: dc.date.available2022-02-22T00:28:18Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jddst.2019.101445-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/199778-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/199778-
Descrição: dc.descriptionPolymer microparticles have been regarded a promising system for drug delivery. In this paper, ionic cross-linking (IC) and dual cross-linking (DC) (ionic/covalent) processes were addressed for the design of innovative microparticles based on gellan gum (GG) and retrograded starch (RS) blends in order to investigate the effect of cross-linking processes on the physicochemical and functional properties of the system. High yield values (>78%) and encapsulation efficiency (around 72%) were achieved. Microparticles were spherical and the particle size ranged from 1016 to 1384 μm. Both cross-linking processes increased the microparticles thermal stability. Starch retrogradation restricted the digestibility by α-amylase pancreatic, so that resistant starch content was above 50%. In general, both IC and DC processes associated to high polymer concentration restricted the microparticles swelling at different pH values (1.2, 7.4 and 6.0) and the increased gellan concentration (2%) improved the mucoadhesiveness. M253ICKT, M255IC-KT and M21053DC-KT microparticles released the lowest amount of drug in acidic media (<17%) and different levels of control of drug release rates were achieved in phosphate buffer, making them potential platforms for colonic drug delivery, attending different therapeutic needs.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionUNESP São Paulo State University School of Pharmaceutical Sciences Department of Drugs and Medicines, km 1 Araraquara-Jaú Road-
Descrição: dc.descriptionUNESP São Paulo State University School of Pharmaceutical Sciences Department of Drugs and Medicines, km 1 Araraquara-Jaú Road-
Descrição: dc.descriptionCAPES: 001-
Idioma: dc.languageen-
Relação: dc.relationJournal of Drug Delivery Science and Technology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectControlled release-
Palavras-chave: dc.subjectDual cross-linking-
Palavras-chave: dc.subjectIonic cross-linking-
Palavras-chave: dc.subjectKetoprofen-
Palavras-chave: dc.subjectMucoadhesion-
Palavras-chave: dc.subjectPolysaccharides-
Título: dc.titleInsights into the impact of cross-linking processes on physicochemical characteristics and mucoadhesive potential of gellan gum/retrograded starch microparticles as a platform for colonic drug release-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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