Burdock (Arctium lappa L.) root attenuates preneoplastic lesion development in a diet and thioacetamide-induced model of steatohepatitis-associated hepatocarcinogenesis

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorHospital Israelita Albert Einstein-
Autor(es): dc.contributorVrije Universiteit Brussel (VUB)-
Autor(es): dc.creatorRomualdo, Guilherme R. [UNESP]-
Autor(es): dc.creatorSilva, Elizangela dos Anjos-
Autor(es): dc.creatorDa Silva, Tereza C.-
Autor(es): dc.creatorAloia, Thiago P. A.-
Autor(es): dc.creatorNogueira, Marina S.-
Autor(es): dc.creatorDe Castro, Inar A.-
Autor(es): dc.creatorVinken, Mathieu-
Autor(es): dc.creatorBarbisan, Luís F. [UNESP]-
Autor(es): dc.creatorCogliati, Bruno-
Data de aceite: dc.date.accessioned2022-02-22T00:28:17Z-
Data de disponibilização: dc.date.available2022-02-22T00:28:17Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-04-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/tox.22887-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/199770-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/199770-
Descrição: dc.descriptionNonalcoholic steatohepatitis (NASH) is considered growing risk factor for hepatocellular carcinoma development in high-income countries. Diet- and chemically induced rodent models have been applied for the translational study of NASH-associated hepatocarcinogenesis due to their morphological and molecular similarities to the corresponding human disease. Arctium lappa L. (burdock) root tea has been extensively consumed in Traditional Chinese Medicine due to its potential therapeutic properties. Indeed, the bioactive compounds of A. lappa root, as the polyphenols, have already showed antioxidant and anti-inflammatory properties in different in vivo and in vitro bioassays. In this study, we investigated whether burdock root ethanolic extract (BRE) administration attenuates NASH-associated hepatocarcinogenesis. Eight-week-old male Wistar rats received choline-deficient high-fat diet for 8 weeks and multiple thioacetamide doses for 4 weeks in order to induce NASH and preneoplastic glutathione-S-transferase pi (GST-P)+ preneoplastic foci. Subsequently, rats were treated with BRE (100 or 200 mg/kg body weight) or vehicle by oral gavage for 2 weeks. BRE displayed high levels of chlorogenic and caffeic acids and BRE administration reduced total fatty acid and lipid hydroperoxide levels, while increasing the activities of antioxidant superoxide dismutase and catalase enzymes in the liver. Furthermore, burdock intervention diminished the size of GST-P+ remodeling preneoplastic lesions (PNLs) and displayed a trend on reducing hepatocyte proliferation (Ki-67) inside them. These findings suggest that short-term exposure to BRE alleviated remodeling PNL development in NASH-associated hepatocarcinogenesis.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Pathology Botucatu Medical School São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Pathology School of Veterinary Medicine and Animal Science University of São Paulo (USP)-
Descrição: dc.descriptionExperimental Research Center Hospital Israelita Albert Einstein-
Descrição: dc.descriptionDepartment of Food and Experimental Nutrition Faculty of Pharmaceutical Sciences University of São Paulo (USP)-
Descrição: dc.descriptionDepartment of in vitro Toxicology and Dermato-Cosmetology Faculty of Medicine and Pharmacy Vrije Universiteit Brussel (VUB)-
Descrição: dc.descriptionDepartment of Morphology Biosciences Institute São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Pathology Botucatu Medical School São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Morphology Biosciences Institute São Paulo State University (UNESP)-
Descrição: dc.descriptionFAPESP: #2016/12015-0-
Descrição: dc.descriptionCNPq: 475459/2011-3-
Formato: dc.format518-527-
Idioma: dc.languageen-
Relação: dc.relationEnvironmental Toxicology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectburdock (Arctium lappa L.)-
Palavras-chave: dc.subjectchlorogenic acid-
Palavras-chave: dc.subjectGST-P+ preneoplastic lesions-
Palavras-chave: dc.subjectnonalcoholic steatohepatitis-
Palavras-chave: dc.subjectrat hepatocarcinogenesis-
Título: dc.titleBurdock (Arctium lappa L.) root attenuates preneoplastic lesion development in a diet and thioacetamide-induced model of steatohepatitis-associated hepatocarcinogenesis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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