SMARCB1 (INI-1) and NUT immunoexpression in a large series of head and neck carcinomas in a Brazilian reference center

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorNeves-Silva, Rodrigo-
Autor(es): dc.creatorAlmeida, Luciana Y. [UNESP]-
Autor(es): dc.creatorSilveira, Heitor A. [UNESP]-
Autor(es): dc.creatorColturato, Carla B. N.-
Autor(es): dc.creatorDuarte, Andressa-
Autor(es): dc.creatorFerrisse, Tulio M. [UNESP]-
Autor(es): dc.creatorSilva, Evânio V. [UNESP]-
Autor(es): dc.creatorVanzolin, Bárbara F.-
Autor(es): dc.creatorBufalino, Andreia [UNESP]-
Autor(es): dc.creatorRibeiro-Silva, Alfredo-
Autor(es): dc.creatorLeón, Jorge E.-
Data de aceite: dc.date.accessioned2022-02-22T00:28:06Z-
Data de disponibilização: dc.date.available2022-02-22T00:28:06Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/hed.26008-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/199707-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/199707-
Descrição: dc.descriptionBackground: SMARCB1 (INI-1)-deficient carcinomas and NUT carcinomas are aggressive neoplasms, often affecting the sinonasal region. Not uncommonly, their diagnoses are made retrospectively. Methods: Through SMARCB1 (INI-1) and NUT immunomarkers, 643 head and neck carcinomas were assessed retrospectively. Moreover, SMARCB1 (INI-1)-deficient and NUT carcinomas were additionally evaluated by immunohistochemistry, as well as in situ hybridization analysis for HPV and EBV. Results: Four SMARCB1 (INI-1)-deficient carcinomas (located in lower lip, soft palate, hypopharynx and vocal cord, this latter high-risk HPV positive) and three NUT carcinomas (all located in oropharynx) were detected, previously diagnosed as nonkeratinizing or moderately differentiated squamous cell carcinoma. All cases showed squamous differentiation. NUT carcinomas than SMARCB1 (INI-1)-deficient carcinomas showed low overall survival rate. Conclusion: The current cases expand the clinicopathological spectrum of SMARCB1 (INI-1)-deficient carcinomas and NUT carcinomas. Notably, the diagnosis of these cases is easily reached through immunohistochemistry, with impact on their accurate classification, treatment, and prognosis.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionOral Pathology Department of Stomatology Public Oral Health and Forensic Dentistry Ribeirão Preto Dental School (FORP/USP) University of São Paulo-
Descrição: dc.descriptionOral Medicine Department of Diagnosis and Surgery Araraquara Dental School São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Pathology and Forensic Medicine Ribeirão Preto Medical School (FMRP/USP) University of São Paulo-
Descrição: dc.descriptionOral Medicine Department of Diagnosis and Surgery Araraquara Dental School São Paulo State University (UNESP)-
Descrição: dc.descriptionFAPESP: 2016/02713-2-
Descrição: dc.descriptionFAPESP: 2016/11419-0-
Descrição: dc.descriptionFAPESP: 2018/12734-2-
Formato: dc.format374-384-
Idioma: dc.languageen-
Relação: dc.relationHead and Neck-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjecthead and neck squamous cell carcinoma-
Palavras-chave: dc.subjectimmunohistochemistry-
Palavras-chave: dc.subjectin situ hybridization-
Palavras-chave: dc.subjectNUT midline carcinoma-
Palavras-chave: dc.subjectSMARCB1 (INI-1)-deficient carcinoma-
Título: dc.titleSMARCB1 (INI-1) and NUT immunoexpression in a large series of head and neck carcinomas in a Brazilian reference center-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.