Mucoadhesive films based on gellan gum/pectin blends as potential platform for buccal drug delivery

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversity of Albstadt-Sigmaringen-
Autor(es): dc.creatorPrezotti, Fabíola Garavello [UNESP]-
Autor(es): dc.creatorSiedle, Izabel-
Autor(es): dc.creatorBoni, Fernanda Isadora [UNESP]-
Autor(es): dc.creatorChorilli, Marlus [UNESP]-
Autor(es): dc.creatorMüller, Ingrid-
Autor(es): dc.creatorCury, Beatriz Stringhetti Ferreira [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:28:01Z-
Data de disponibilização: dc.date.available2022-02-22T00:28:01Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-02-06-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/10837450.2019.1682608-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/199676-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/199676-
Descrição: dc.descriptionFilms of gellan gum:pectin blends were prepared by solvent casting method. Gellan gum:pectin mass ratios were varied (4:1; 1:1; 1:4) at different concentrations (3% or 4%) and glycerol was used as plasticizer (1 or 2%). The films were thin (18–30 µm), translucent, flexible, and homogeneous. The surface pH was suitable for buccal application. All films reached high mechanical resistance and the mucoadhesive ability of them was evidenced. High ratio of gellan gum improved the mechanical resistance and the mucoadhesion of the films as well as the control of drug release rates. The films did not disintegrate in simulate saliva up to 24 h and curcumin release could be sustained up to 12 h. The set of data evidence that the films designed in this work represent a potential platform for buccal drug delivery.-
Descrição: dc.descriptionDepartment of Drugs and Pharmaceuticals School of Pharmaceutical Sciences São Paulo State University UNESP-
Descrição: dc.descriptionFaculty for Pharmaceutical Engineering University of Albstadt-Sigmaringen-
Descrição: dc.descriptionDepartment of Drugs and Pharmaceuticals School of Pharmaceutical Sciences São Paulo State University UNESP-
Formato: dc.format159-167-
Idioma: dc.languageen-
Relação: dc.relationPharmaceutical Development and Technology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcontrolled release-
Palavras-chave: dc.subjectmechanical properties-
Palavras-chave: dc.subjectmucoadhesion-
Palavras-chave: dc.subjectSolvent casting method-
Palavras-chave: dc.subjectswelling ability-
Palavras-chave: dc.subjectwater vapor permeability-
Título: dc.titleMucoadhesive films based on gellan gum/pectin blends as potential platform for buccal drug delivery-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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