Bactericidal effect of pyridine-2-thiol 1-oxide sodium salt and its complex with iron against resistant clinical isolates of Mycobacterium tuberculosis

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidad de la República-
Autor(es): dc.creatorCampos, Debora L. [UNESP]-
Autor(es): dc.creatorMachado, Ignacio-
Autor(es): dc.creatorRibeiro, Camila M. [UNESP]-
Autor(es): dc.creatorGambino, Dinorah-
Autor(es): dc.creatorPavan, Fernando R. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:27:50Z-
Data de disponibilização: dc.date.available2022-02-22T00:27:50Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1038/s41429-019-0243-3-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/199613-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/199613-
Descrição: dc.descriptionThe objective of this study was to determine the activity of pyridine-2-thiol 1-oxide sodium salt (Na mpo) and its complex with iron [Fe(mpo)3] against Mycobacterium tuberculosis. The compounds were tested against a standard strain of M. tuberculosis H37Rv (ATCC 27294), with minimal inhibitory concentrations (MIC90) of 7.20 and 1.07 μM to Na mpo and [Fe(mpo)3], respectively, and against three clinical isolates with different genotypic profiles, with MIC values ranging from 0.74 to 6.52 and 0.30 to 2.25 μM to Na mpo and [Fe(mpo)3], respectively. [Fe(mpo)3] was more effective against susceptible strains but both compounds were effective in inhibiting MDR and XDR-TB clinical strains. The profile activity was determined through the methodology of a time-kill curve against standard and clinical strains of M. tuberculosis. Time-kill studies indicated that Na mpo had an early bactericidal activity against H37Rv and clinical isolates, with sterilizing effects observed in 5 and 7 days, respectively, at its MIC90. The anti MDR and XDR-M. tuberculosis activity and bactericidal effect of Na mpo and [Fe(mpo)3] demonstrate their potential as new compounds for the treatment of tuberculosis.-
Descrição: dc.descriptionDepartment of Biological Sciences Faculty of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionÁrea Química Analítica Facultad de Química Universidad de la República-
Descrição: dc.descriptionÁrea Química Inorgánica Facultad de Química Universidad de la República-
Descrição: dc.descriptionDepartment of Biological Sciences Faculty of Pharmaceutical Sciences São Paulo State University (UNESP)-
Formato: dc.format120-124-
Idioma: dc.languageen-
Relação: dc.relationJournal of Antibiotics-
???dc.source???: dc.sourceScopus-
Título: dc.titleBactericidal effect of pyridine-2-thiol 1-oxide sodium salt and its complex with iron against resistant clinical isolates of Mycobacterium tuberculosis-
Tipo de arquivo: dc.typelivro digital-
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