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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | University of Franca (UNIFRAN) | - |
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.contributor | Science and Technology of the South of Minas Gerais - Muzambinho | - |
Autor(es): dc.contributor | Veterinary Pathologist at the CEVEPAT Laboratory | - |
Autor(es): dc.contributor | Universidade Paulista – UNIP | - |
Autor(es): dc.creator | Dos Anjos, Denner S. | - |
Autor(es): dc.creator | Bueno, Cynthia [UNESP] | - |
Autor(es): dc.creator | Magalhães, Larissa F. | - |
Autor(es): dc.creator | Magalhães, Georgia M. | - |
Autor(es): dc.creator | Mattos-Junior, Ewaldo | - |
Autor(es): dc.creator | Pinto, Marcela M. R. | - |
Autor(es): dc.creator | De Nardi, Andrigo B. [UNESP] | - |
Autor(es): dc.creator | Brunner, Carlos H. M. | - |
Autor(es): dc.creator | Leis-Filho, Antonio F. [UNESP] | - |
Autor(es): dc.creator | Calazans, Sabryna G. | - |
Autor(es): dc.creator | Fonseca-Alves, Carlos E. [UNESP] | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:27:46Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:27:46Z | - |
Data de envio: dc.date.issued | 2020-12-11 | - |
Data de envio: dc.date.issued | 2020-12-11 | - |
Data de envio: dc.date.issued | 2019-11-30 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1038/s41598-019-52461-6 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/199587 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/199587 | - |
Descrição: dc.description | Canine cutaneous squamous cell carcinoma (cSCC) is the most common skin cancer in dogs, and, due to its low metastatic rate, local treatments, such as electrochemotherapy (ECT), promote disease control or even complete remission (CR). This study aimed to evaluate the gene and protein expression of Bcl-2 and Bcl-2 associated X protein (BAX), the proliferative index and clinical parameters in dogs with cSCC subjected to ECT. A prospective nonrandomized clinical study was performed using dogs with naturally occurring cSCC that was treated with ECT. Eighteen lesions from 11 dogs were selected. The tumor size at day 0 (D0) had no impact on survival or prognosis (P > 0.05). Tumor samples had a lower proliferative index after ECT (D21) than before ECT (P = 0.031). The survival of subjects with Ki67 values lower and higher than the Ki67 median value were not significantly different (P > 0.05). Regarding apoptotic markers, there were no significant differences in the gene and protein expression levels of BAX or Bcl-2 at D0 and D21 (P > 0.05) or in the overall survival of subjects with different levels of apoptotic markers. In conclusion, there was no change in BAX or Bcl-2 gene and protein expression in response to ECT at the time points evaluated, but ECT was able to reduce tumor volume and cellular proliferation in cSCC. | - |
Descrição: dc.description | Veterinary Science Graduate Program University of Franca (UNIFRAN) | - |
Descrição: dc.description | Department of Veterinary Clinic and Surgery São Paulo State University (UNESP) | - |
Descrição: dc.description | Department of Veterinary Pathology University of Franca (UNIFRAN) | - |
Descrição: dc.description | Federal Institute of Education Science and Technology of the South of Minas Gerais - Muzambinho | - |
Descrição: dc.description | Veterinary Pathologist at the CEVEPAT Laboratory | - |
Descrição: dc.description | Department of Veterinary Clinic of University Paulista | - |
Descrição: dc.description | Department of Veterinary Clinic School of Veterinary Medicine and Animal Science São Paulo State University (UNESP) | - |
Descrição: dc.description | Institute of Health Sciences Universidade Paulista – UNIP | - |
Descrição: dc.description | Department of Veterinary Clinic and Surgery São Paulo State University (UNESP) | - |
Descrição: dc.description | Department of Veterinary Clinic School of Veterinary Medicine and Animal Science São Paulo State University (UNESP) | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Scientific Reports | - |
???dc.source???: dc.source | Scopus | - |
Título: dc.title | Electrochemotherapy induces tumor regression and decreases the proliferative index in canine cutaneous squamous cell carcinoma | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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