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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Universidade de São Paulo (USP) | - |
Autor(es): dc.contributor | Federal University of Juiz de Fora | - |
Autor(es): dc.contributor | Hospital de Clinicas da Universidade Federal do Parana | - |
Autor(es): dc.contributor | Hospital de Clinicas de Porto Alegre | - |
Autor(es): dc.contributor | Universidade Federal do Piaui | - |
Autor(es): dc.contributor | Hospital de Clínicas da Universidade Federal do Parana | - |
Autor(es): dc.contributor | CTI Clinical Trial and Consulting Services | - |
Autor(es): dc.contributor | CMIP Centro Mineiro de Pesquisa | - |
Autor(es): dc.contributor | Hospital Nossa Senhora das Gracas | - |
Autor(es): dc.contributor | Hospital Universitario da Universidade Federal do Piaui | - |
Autor(es): dc.contributor | Universidade Federal do Rio de Janeiro (UFRJ) | - |
Autor(es): dc.contributor | Universidade do Estado da Bahia | - |
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.contributor | Instituto Goiano de Gastroenterologia e Endoscopia Digestiva Ltda | - |
Autor(es): dc.contributor | Kaiser Clinica | - |
Autor(es): dc.contributor | Escola Paulista de Medicina | - |
Autor(es): dc.contributor | Universidade Federal de São Paulo (UNIFESP) | - |
Autor(es): dc.contributor | Faculdade de Medicina do ABC | - |
Autor(es): dc.contributor | Universidade Federal de Minas Gerais (UFMG) | - |
Autor(es): dc.contributor | Takeda Pharmaceuticals Brazil | - |
Autor(es): dc.creator | Parra, Rogerio S. | - |
Autor(es): dc.creator | Chebli, Julio M.F. | - |
Autor(es): dc.creator | Amarante, Heda M.B.S. | - |
Autor(es): dc.creator | Flores, Cristina | - |
Autor(es): dc.creator | Parente, Jose M.L. | - |
Autor(es): dc.creator | Ramos, Odery | - |
Autor(es): dc.creator | Fernandes, Milene | - |
Autor(es): dc.creator | Rocha, Jose J.R. | - |
Autor(es): dc.creator | Feitosa, Marley R. | - |
Autor(es): dc.creator | Feres, Omar | - |
Autor(es): dc.creator | Scotton, Antonio S. | - |
Autor(es): dc.creator | Nones, Rodrigo B. | - |
Autor(es): dc.creator | Lima, Murilo M. | - |
Autor(es): dc.creator | Zaltman, Cyrla | - |
Autor(es): dc.creator | Goncalves, Carolina D. | - |
Autor(es): dc.creator | Guimaraes, Isabella M. | - |
Autor(es): dc.creator | Santana, Genoile O. | - |
Autor(es): dc.creator | Sassaki, Ligia Y. [UNESP] | - |
Autor(es): dc.creator | Hossne, Rogerio S. [UNESP] | - |
Autor(es): dc.creator | Bafutto, Mauro | - |
Autor(es): dc.creator | Roberto, L. K. | - |
Autor(es): dc.creator | Faria, Mikaell A.G. | - |
Autor(es): dc.creator | Miszputen, Sender J. | - |
Autor(es): dc.creator | Gomes, Tarcia N.F. | - |
Autor(es): dc.creator | Catapani, Wilson R. | - |
Autor(es): dc.creator | Faria, Anderson A. | - |
Autor(es): dc.creator | Souza, Stella C.S. | - |
Autor(es): dc.creator | Caratin, Rosana F. | - |
Autor(es): dc.creator | Senra, Juliana T. | - |
Autor(es): dc.creator | Ferrari, Maria L.A. | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:27:35Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:27:35Z | - |
Data de envio: dc.date.issued | 2020-12-11 | - |
Data de envio: dc.date.issued | 2020-12-11 | - |
Data de envio: dc.date.issued | 2019-10-14 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.3748/wjg.v25.i38.5862 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/199521 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/199521 | - |
Descrição: dc.description | Background: Inflammatory bowel diseases (IBD) have been associated with a low quality of life (QoL) and a negative impact on work productivity compared to the general population. Information about disease control, patient-reported outcomes (PROs), treatment patterns and use of healthcare resources is relevant to optimizing IBD management. Aim: To describe QoL and work productivity and activity impairment (WPAI), treatment patterns and use of healthcare resources among IBD patients in Brazil. Methods: A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn's disease (CD) or ulcerative colitis (UC). At enrolment, active CD and UC were defined as having a Harvey Bradshaw Index ≥ 8 or a CD Activity Index ≥ 220 or calprotectin > 200 μg/g or previous colonoscopy results suggestive of inadequate control (per investigator criteria) and a 9-point partial Mayo score ≥ 5, respectively. The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L, the Inflammatory Bowel Disease Questionnaire (IBDQ), and the WPAI questionnaire. Information about healthcare resources and treatment during the previous 3 years was collected from medical records. Chi-square, Fisher's exact and Student's t-/Mann-Whitney U tests were used to compare PROs, treatment patterns and the use of healthcare resources by disease activity (α = 0.05). Results: Of the 407 patients in this study (CD/UC: 64.9%/35.1%, mean age 42.9/45.9 years, 54.2%/56.6% female, 38.3%/37.1% employed), 44.7%/25.2% presented moderate-to-severe CD/UC activity, respectively, at baseline. Expressed in median values for CD/UC, respectively, the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2, the EQ-visual analog scale score was 80.0/70.0, and the IBDQ overall score was 164.0/165.0. Moderate to severe activity, female gender, being unemployed, a lower educational level and lower income were associated with lower QoL (P < 0.05). Median work productivity impairment was 20% and 5% for CD and UC patients, respectively, and activity impairment was 30%, the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity (75.0% vs 10.0%, P < 0.001). For CD/UC patients, respectively, 25.4%/2.8% had at least one surgery, 38.3%/19.6% were hospitalized, and 70.7%/77.6% changed IBD treatment at least once during the last 3 years. The most common treatments at baseline were biologics (75.3%) and immunosuppressants (70.9%) for CD patients and 5-ASA compounds (77.5%) for UC patients. Conclusion: Moderate to severe IBD activity, especially among CD patients, is associated with a substantial impact on QoL, work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | - |
Descrição: dc.description | AbbVie | - |
Descrição: dc.description | Ferring Pharmaceuticals | - |
Descrição: dc.description | Pfizer | - |
Descrição: dc.description | Department of Surgery and Anatomy Ribeirao Preto Medical School University of Sao Paulo | - |
Descrição: dc.description | Inflammatory Bowel Disease Center Federal University of Juiz de Fora | - |
Descrição: dc.description | Hospital de Clinicas da Universidade Federal do Parana | - |
Descrição: dc.description | Hospital de Clinicas de Porto Alegre | - |
Descrição: dc.description | Universidade Federal do Piaui | - |
Descrição: dc.description | Hospital de Clínicas da Universidade Federal do Parana | - |
Descrição: dc.description | CTI Clinical Trial and Consulting Services | - |
Descrição: dc.description | CMIP Centro Mineiro de Pesquisa | - |
Descrição: dc.description | Hospital Nossa Senhora das Gracas | - |
Descrição: dc.description | Hospital Universitario da Universidade Federal do Piaui | - |
Descrição: dc.description | Universidade Federal do Rio de Janeiro | - |
Descrição: dc.description | Universidade do Estado da Bahia | - |
Descrição: dc.description | Department of Internal Medicine Botucatu Medical School at Sao Paulo State University (UNESP) | - |
Descrição: dc.description | Instituto Goiano de Gastroenterologia e Endoscopia Digestiva Ltda | - |
Descrição: dc.description | Kaiser Clinica | - |
Descrição: dc.description | Escola Paulista de Medicina | - |
Descrição: dc.description | UNIFESP Disciplina de Gastroenterologia | - |
Descrição: dc.description | Faculdade de Medicina do ABC | - |
Descrição: dc.description | Faculdade de Medicina UFMG | - |
Descrição: dc.description | Takeda Pharmaceuticals Brazil | - |
Descrição: dc.description | Department of Internal Medicine Botucatu Medical School at Sao Paulo State University (UNESP) | - |
Formato: dc.format | 5862-5882 | - |
Idioma: dc.language | en | - |
Relação: dc.relation | World Journal of Gastroenterology | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | Crohn's disease | - |
Palavras-chave: dc.subject | Healthcare resources | - |
Palavras-chave: dc.subject | Inflammatory bowel disease | - |
Palavras-chave: dc.subject | Quality of life | - |
Palavras-chave: dc.subject | Ulcerative colitis | - |
Título: dc.title | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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