Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorFederal University of Juiz de Fora-
Autor(es): dc.contributorHospital de Clinicas da Universidade Federal do Parana-
Autor(es): dc.contributorHospital de Clinicas de Porto Alegre-
Autor(es): dc.contributorUniversidade Federal do Piaui-
Autor(es): dc.contributorHospital de Clínicas da Universidade Federal do Parana-
Autor(es): dc.contributorCTI Clinical Trial and Consulting Services-
Autor(es): dc.contributorCMIP Centro Mineiro de Pesquisa-
Autor(es): dc.contributorHospital Nossa Senhora das Gracas-
Autor(es): dc.contributorHospital Universitario da Universidade Federal do Piaui-
Autor(es): dc.contributorUniversidade Federal do Rio de Janeiro (UFRJ)-
Autor(es): dc.contributorUniversidade do Estado da Bahia-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorInstituto Goiano de Gastroenterologia e Endoscopia Digestiva Ltda-
Autor(es): dc.contributorKaiser Clinica-
Autor(es): dc.contributorEscola Paulista de Medicina-
Autor(es): dc.contributorUniversidade Federal de São Paulo (UNIFESP)-
Autor(es): dc.contributorFaculdade de Medicina do ABC-
Autor(es): dc.contributorUniversidade Federal de Minas Gerais (UFMG)-
Autor(es): dc.contributorTakeda Pharmaceuticals Brazil-
Autor(es): dc.creatorParra, Rogerio S.-
Autor(es): dc.creatorChebli, Julio M.F.-
Autor(es): dc.creatorAmarante, Heda M.B.S.-
Autor(es): dc.creatorFlores, Cristina-
Autor(es): dc.creatorParente, Jose M.L.-
Autor(es): dc.creatorRamos, Odery-
Autor(es): dc.creatorFernandes, Milene-
Autor(es): dc.creatorRocha, Jose J.R.-
Autor(es): dc.creatorFeitosa, Marley R.-
Autor(es): dc.creatorFeres, Omar-
Autor(es): dc.creatorScotton, Antonio S.-
Autor(es): dc.creatorNones, Rodrigo B.-
Autor(es): dc.creatorLima, Murilo M.-
Autor(es): dc.creatorZaltman, Cyrla-
Autor(es): dc.creatorGoncalves, Carolina D.-
Autor(es): dc.creatorGuimaraes, Isabella M.-
Autor(es): dc.creatorSantana, Genoile O.-
Autor(es): dc.creatorSassaki, Ligia Y. [UNESP]-
Autor(es): dc.creatorHossne, Rogerio S. [UNESP]-
Autor(es): dc.creatorBafutto, Mauro-
Autor(es): dc.creatorRoberto, L. K.-
Autor(es): dc.creatorFaria, Mikaell A.G.-
Autor(es): dc.creatorMiszputen, Sender J.-
Autor(es): dc.creatorGomes, Tarcia N.F.-
Autor(es): dc.creatorCatapani, Wilson R.-
Autor(es): dc.creatorFaria, Anderson A.-
Autor(es): dc.creatorSouza, Stella C.S.-
Autor(es): dc.creatorCaratin, Rosana F.-
Autor(es): dc.creatorSenra, Juliana T.-
Autor(es): dc.creatorFerrari, Maria L.A.-
Data de aceite: dc.date.accessioned2022-02-22T00:27:35Z-
Data de disponibilização: dc.date.available2022-02-22T00:27:35Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2019-10-14-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3748/wjg.v25.i38.5862-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/199521-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/199521-
Descrição: dc.descriptionBackground: Inflammatory bowel diseases (IBD) have been associated with a low quality of life (QoL) and a negative impact on work productivity compared to the general population. Information about disease control, patient-reported outcomes (PROs), treatment patterns and use of healthcare resources is relevant to optimizing IBD management. Aim: To describe QoL and work productivity and activity impairment (WPAI), treatment patterns and use of healthcare resources among IBD patients in Brazil. Methods: A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn's disease (CD) or ulcerative colitis (UC). At enrolment, active CD and UC were defined as having a Harvey Bradshaw Index ≥ 8 or a CD Activity Index ≥ 220 or calprotectin > 200 μg/g or previous colonoscopy results suggestive of inadequate control (per investigator criteria) and a 9-point partial Mayo score ≥ 5, respectively. The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L, the Inflammatory Bowel Disease Questionnaire (IBDQ), and the WPAI questionnaire. Information about healthcare resources and treatment during the previous 3 years was collected from medical records. Chi-square, Fisher's exact and Student's t-/Mann-Whitney U tests were used to compare PROs, treatment patterns and the use of healthcare resources by disease activity (α = 0.05). Results: Of the 407 patients in this study (CD/UC: 64.9%/35.1%, mean age 42.9/45.9 years, 54.2%/56.6% female, 38.3%/37.1% employed), 44.7%/25.2% presented moderate-to-severe CD/UC activity, respectively, at baseline. Expressed in median values for CD/UC, respectively, the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2, the EQ-visual analog scale score was 80.0/70.0, and the IBDQ overall score was 164.0/165.0. Moderate to severe activity, female gender, being unemployed, a lower educational level and lower income were associated with lower QoL (P < 0.05). Median work productivity impairment was 20% and 5% for CD and UC patients, respectively, and activity impairment was 30%, the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity (75.0% vs 10.0%, P < 0.001). For CD/UC patients, respectively, 25.4%/2.8% had at least one surgery, 38.3%/19.6% were hospitalized, and 70.7%/77.6% changed IBD treatment at least once during the last 3 years. The most common treatments at baseline were biologics (75.3%) and immunosuppressants (70.9%) for CD patients and 5-ASA compounds (77.5%) for UC patients. Conclusion: Moderate to severe IBD activity, especially among CD patients, is associated with a substantial impact on QoL, work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil.-
Descrição: dc.descriptionAbbVie-
Descrição: dc.descriptionFerring Pharmaceuticals-
Descrição: dc.descriptionPfizer-
Descrição: dc.descriptionDepartment of Surgery and Anatomy Ribeirao Preto Medical School University of Sao Paulo-
Descrição: dc.descriptionInflammatory Bowel Disease Center Federal University of Juiz de Fora-
Descrição: dc.descriptionHospital de Clinicas da Universidade Federal do Parana-
Descrição: dc.descriptionHospital de Clinicas de Porto Alegre-
Descrição: dc.descriptionUniversidade Federal do Piaui-
Descrição: dc.descriptionHospital de Clínicas da Universidade Federal do Parana-
Descrição: dc.descriptionCTI Clinical Trial and Consulting Services-
Descrição: dc.descriptionCMIP Centro Mineiro de Pesquisa-
Descrição: dc.descriptionHospital Nossa Senhora das Gracas-
Descrição: dc.descriptionHospital Universitario da Universidade Federal do Piaui-
Descrição: dc.descriptionUniversidade Federal do Rio de Janeiro-
Descrição: dc.descriptionUniversidade do Estado da Bahia-
Descrição: dc.descriptionDepartment of Internal Medicine Botucatu Medical School at Sao Paulo State University (UNESP)-
Descrição: dc.descriptionInstituto Goiano de Gastroenterologia e Endoscopia Digestiva Ltda-
Descrição: dc.descriptionKaiser Clinica-
Descrição: dc.descriptionEscola Paulista de Medicina-
Descrição: dc.descriptionUNIFESP Disciplina de Gastroenterologia-
Descrição: dc.descriptionFaculdade de Medicina do ABC-
Descrição: dc.descriptionFaculdade de Medicina UFMG-
Descrição: dc.descriptionTakeda Pharmaceuticals Brazil-
Descrição: dc.descriptionDepartment of Internal Medicine Botucatu Medical School at Sao Paulo State University (UNESP)-
Formato: dc.format5862-5882-
Idioma: dc.languageen-
Relação: dc.relationWorld Journal of Gastroenterology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCrohn's disease-
Palavras-chave: dc.subjectHealthcare resources-
Palavras-chave: dc.subjectInflammatory bowel disease-
Palavras-chave: dc.subjectQuality of life-
Palavras-chave: dc.subjectUlcerative colitis-
Título: dc.titleQuality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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