Antimicrobial photodynamic therapy in combination with nystatin in the treatment of experimental oral candidiasis induced by candida albicans resistant to fluconazole

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorJaneth Rimachi Hidalgo, Karem [UNESP]-
Autor(es): dc.creatorCabrini Carmello, Juliana [UNESP]-
Autor(es): dc.creatorCarolina Jordão, Cláudia [UNESP]-
Autor(es): dc.creatorAboud Barbugli, Paula [UNESP]-
Autor(es): dc.creatorde Sousa Costa, Carlos Alberto [UNESP]-
Autor(es): dc.creatorGarcia de Oliveira Mima, Ewerton [UNESP]-
Autor(es): dc.creatorPavarina, Ana Claudia [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:27:32Z-
Data de disponibilização: dc.date.available2022-02-22T00:27:32Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2019-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ph12030140-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/199504-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/199504-
Descrição: dc.descriptionBackground: It has been demonstrated that azole-resistant strains of Candida albicans have a greater resistance to antimicrobial photodynamic therapy (aPDT) when compared to their more susceptible counterparts. For this reason, the present study evaluated the efficacy of aPDT, together with nystatin (NYS), in the treatment of oral candidiasis in vivo. Methods: Mice were infected with fluconazole-resistant C. albicans (ATCC 96901). To perform the combined therapy, aPDT, mediated by Photodithazine (PDZ) and LED light, was used together with NYS. The efficacy of the treatments was evaluated by microbiological, macroscopic, histopathological and Confocal Scanning Laser Microscopy analyses of the lesions. The expression of p21 and p53, proteins associated with cell death, from the tongues of mice, was also performed. Results: The combined therapy reduced the fungal viability by around 2.6 log10 and decreased the oral lesions and the inflammatory reaction. Additionally, it stimulated the production of p53 and p21. Conclusions: The combined therapy is a promising alternative treatment for oral candidiasis induced by C. albicans resistant to fluconazole.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionUniversidade de São Paulo-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics School of Dentistry São Paulo State University (Unesp) Araraquara, Rua Humaitá, 1680-
Descrição: dc.descriptionDepartment of Physiology and Pathology School of Dentistry São Paulo State University (Unesp) Araraquara, Rua Humaitá, 1680-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics School of Dentistry São Paulo State University (Unesp) Araraquara, Rua Humaitá, 1680-
Descrição: dc.descriptionDepartment of Physiology and Pathology School of Dentistry São Paulo State University (Unesp) Araraquara, Rua Humaitá, 1680-
Descrição: dc.descriptionFAPESP: 13/07276-1-
Idioma: dc.languageen-
Relação: dc.relationPharmaceuticals-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntifungals-
Palavras-chave: dc.subjectCandida albicans-
Palavras-chave: dc.subjectPhotodynamic therapy-
Título: dc.titleAntimicrobial photodynamic therapy in combination with nystatin in the treatment of experimental oral candidiasis induced by candida albicans resistant to fluconazole-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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