Glucose is an active chemical agent on degradation of hydroxyapatite nanostructure

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorPontifical Catholic University of Goias-
Autor(es): dc.contributorPaul Langerhans Institute Dresden of the Helmholtz Zentrum München at the University Hospital and Faculty of Medicine Carl Gustav Carus of TU Dresden-
Autor(es): dc.contributorPontifical Catholic University of Goiás-
Autor(es): dc.contributorState University of Goiás (UEG)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorMartins, Murillo L.-
Autor(es): dc.creatorIessi, Isabela L.-
Autor(es): dc.creatorQuintino, Michelle P.-
Autor(es): dc.creatorDamasceno, Débora C. [UNESP]-
Autor(es): dc.creatorRodrigues, Cloves G.-
Data de aceite: dc.date.accessioned2022-02-22T00:27:19Z-
Data de disponibilização: dc.date.available2022-02-22T00:27:19Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-01-14-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.matchemphys.2019.122166-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/199424-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/199424-
Descrição: dc.descriptionThe mechanisms governing the glucose/bone mineral interface are still not fully described. By recognizing the multidisciplinary character of this problem, in this work we exclude any biological variable and provide insight with a pure materials science perspective. For that, hydroxyapatite nanoparticles were prepared in media with glucose concentrations analogous to those found in healthy and diabetic patients. We report that the influence of glucose over the nanoparticles depends on the stage in which it is added to the synthesis. First, nanoparticles precipitated in glucose-rich solutions present, as expected, decrease in crystallinity. However, this effect is driven by the action of glucose as an active chemical agent, rather than simply as a dispersant. This effect becomes more severe when hydroxyapatite nanoparticles are separately prepared and further allowed to interact with glucose. In this scenario, the deterioration of the nanoparticles’ bulk structure accompanies increase in surface crystallinity. In general, the effects of glucose over hydroxyapatite are concentration-dependent and associated with the precipitation of secondary phases - calcium hydroxide and calcium carbonate. Finally, we present illustrative data from bone minerals from one diabetic and one healthy rat and show that our methods and outcomes are employable in future biomedical investigations.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de Goiás-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionPost-Graduation Program in Industrial and Systems Engineering Pontifical Catholic University of Goias-
Descrição: dc.descriptionPaul Langerhans Institute Dresden of the Helmholtz Zentrum München at the University Hospital and Faculty of Medicine Carl Gustav Carus of TU Dresden-
Descrição: dc.descriptionSchool of Exact Sciences and Computing Pontifical Catholic University of Goiás-
Descrição: dc.descriptionState University of Goiás (UEG)-
Descrição: dc.descriptionLaboratory of Experimental Research on Gynecology and Obstetrics Botucatu Medical School Sao Paulo State University (UNESP)-
Descrição: dc.descriptionLaboratory of Experimental Research on Gynecology and Obstetrics Botucatu Medical School Sao Paulo State University (UNESP)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de Goiás: 20171026700070-
Descrição: dc.descriptionCNPq: 205609/2014-7-
Descrição: dc.descriptionCNPq: 300509/2017-0-
Idioma: dc.languageen-
Relação: dc.relationMaterials Chemistry and Physics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectGlucose-
Palavras-chave: dc.subjectHydroxyapatite-
Palavras-chave: dc.subjectInfrared spectroscopy-
Palavras-chave: dc.subjectX-ray diffraction-
Título: dc.titleGlucose is an active chemical agent on degradation of hydroxyapatite nanostructure-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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