Factors associated with thrombocytopenia in patients with dengue fever: a retrospective cohort study

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversity of Sorocaba (UNISO)-
Autor(es): dc.contributorFaculdade São Leopoldo Mandic-
Autor(es): dc.creatorCastilho, Bruna M. [UNESP]-
Autor(es): dc.creatorSilva, Marcus T.-
Autor(es): dc.creatorFreitas, André R R-
Autor(es): dc.creatorFulone, Izabela-
Autor(es): dc.creatorLopes, Luciane Cruz-
Data de aceite: dc.date.accessioned2022-02-22T00:27:16Z-
Data de disponibilização: dc.date.available2022-02-22T00:27:16Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-09-13-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1136/bmjopen-2019-035120-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/199405-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/199405-
Descrição: dc.descriptionOBJECTIVE: Some patients with dengue fever tend to develop thrombocytopenia during the course of infection and are thus vulnerable to haemorrhagic manifestations and other complications. However, the factors associated with the development of thrombocytopenia are unknown. We aimed to identify factors associated with an increased risk of thrombocytopenia and haematological changes in patients with confirmed dengue fever. DESIGN: Retrospective cohort study. SETTING: Brazilian multicentre primary care databases. PARTICIPANTS: 387 patients had positive laboratory serological confirmation of dengue infection during 2014. The data were identified from two databases: Notification of Injury Information System (SINAN) and Municipal Laboratory. MAIN OUTCOME MEASURE: The presence of thrombocytopenia (platelet count <1 50×109/L). The associations of factors that predisposed patients to thrombocytopenia and haematological changes were analysed using logistic regression. ORs and 95% CIs were calculated. RESULTS: Among 387 patients, 156 had both dengue and thrombocytopenia. The risk factors associated with thrombocytopenia included male sex (OR: 1.77, 95% CI: 1.16 to 2.71, p=0.007), age of 46-64 years (OR: 2.20, 95% CI: 1.15 to 4.21, p=0.009) or ≥65 years (OR: 3.02, 95% CI: 1.40 to 6.50, p=0.002), presence of leucopenia (OR: 6.85, 95% CI: 4.27 to 10.99, p<0.001) and high mean corpuscular haemoglobin (MCH) levels (OR: 2.00, 95% CI: 1.29 to 3.12, p=0.005). CONCLUSION: Older age, male sex, presence of leucopenia and high MCH levels were identified as risk factors associated with the development of thrombocytopenia in this population.-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionPharmaceutical Sciences Graduate Course University of Sorocaba (UNISO)-
Descrição: dc.descriptionFaculdade São Leopoldo Mandic-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University (UNESP)-
Formato: dc.formate035120-
Idioma: dc.languageen-
Relação: dc.relationBMJ open-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectepidemiology-
Palavras-chave: dc.subjectpublic health-
Palavras-chave: dc.subjectvirology-
Título: dc.titleFactors associated with thrombocytopenia in patients with dengue fever: a retrospective cohort study-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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