Fine-scale estimation of inbreeding rates, runs of homozygosity and genome-wide heterozygosity levels in the Mangalarga Marchador horse breed

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade Federal de Minas Gerais (UFMG)-
Autor(es): dc.creatorBizarria dos Santos, Wellington [UNESP]-
Autor(es): dc.creatorPimenta Schettini, Gustavo [UNESP]-
Autor(es): dc.creatorFonseca, Mayara Gonçalves-
Autor(es): dc.creatorPereira, Guilherme Luis [UNESP]-
Autor(es): dc.creatorLoyola Chardulo, Luis Artur [UNESP]-
Autor(es): dc.creatorRodrigues Machado Neto, Otávio [UNESP]-
Autor(es): dc.creatorBaldassini, Welder Angelo [UNESP]-
Autor(es): dc.creatorNunes de Oliveira, Henrique [UNESP]-
Autor(es): dc.creatorAbdallah Curi, Rogério [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:27:16Z-
Data de disponibilização: dc.date.available2022-02-22T00:27:16Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2019-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/jbg.12508-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/199402-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/199402-
Descrição: dc.descriptionWith the availability of high-density SNP panels and the establishment of approaches for characterizing homozygosity and heterozygosity sites, it is possible to access fine-scale information regarding genomes, providing more than just comparisons of different inbreeding coefficients. This is the first study that seeks to access such information for the Mangalarga Marchador (MM) horse breed on a genomic scale. To this end, we aimed to assess inbreeding levels using different coefficients, as well as to characterize homozygous and heterozygous runs in the population. Using Axiom ® Equine Genotyping Array—670k SNP (Thermo Fisher), 192 horses were genotyped. Our results showed different estimates: inbreeding from genomic coefficients (FROH) = 0.16; pedigree-based (FPED) = 0.008; and a method based on excess homozygosity (FHOM) = 0.010. The correlations between the inbreeding coefficients were low to moderate, and some comparisons showed negative correlations, being practically null. In total, 85,295 runs of homozygosity (ROH) and 10,016 runs of heterozygosity (ROHet) were characterized for the 31 horse autosomal chromosomes. The class with the highest percentage of ROH was 0–2 Mbps, with 92.78% of the observations. In the ROHet results, only the 0–2 class presented observations, with chromosome 11 highlighted in a region with high genetic variability. Three regions from the ROHet analyses showed genes with known functions: tripartite motif-containing 37 (TRIM37), protein phosphatase, Mg2+/Mn2+ dependent 1E (PPM1E) and carbonic anhydrase 10 (CA10). Therefore, our findings suggest moderate inbreeding, possibly attributed to breed formation, annulling possible recent inbreeding. Furthermore, regions with high variability in the MM genome were identified (ROHet), associated with the recent selection and important events in the development and performance of MM horses over generations.-
Descrição: dc.descriptionSchool of Agricultural and Veterinary Sciences (FCAV) São Paulo State University (Unesp)-
Descrição: dc.descriptionFederal University of Minas Gerais (UFMG)-
Descrição: dc.descriptionSchool of Veterinary Medicine and Animal Science (FMVZ) São Paulo State University (Unesp)-
Descrição: dc.descriptionSchool of Agricultural and Veterinary Sciences (FCAV) São Paulo State University (Unesp)-
Descrição: dc.descriptionSchool of Veterinary Medicine and Animal Science (FMVZ) São Paulo State University (Unesp)-
Idioma: dc.languageen-
Relação: dc.relationJournal of Animal Breeding and Genetics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectEquus caballus-
Palavras-chave: dc.subjectFHOM-
Palavras-chave: dc.subjectFPED-
Palavras-chave: dc.subjectFROH-
Palavras-chave: dc.subjectROH-
Palavras-chave: dc.subjectROHet-
Título: dc.titleFine-scale estimation of inbreeding rates, runs of homozygosity and genome-wide heterozygosity levels in the Mangalarga Marchador horse breed-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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