Green synthesis of antileishmanial and antifungal silver nanoparticles using corn cob xylan as a reducing and stabilizing agent

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Federal do Rio Grande do Norte-
Autor(es): dc.contributorInstituto de Tecnologia dos Alimentos (ITAL)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade Federal do Paraná (UFPR)-
Autor(es): dc.creatorViana, Rony Lucas Silva-
Autor(es): dc.creatorFidelis, Gabriel Pereira-
Autor(es): dc.creatorMedeiros, Mayara Jane Campos-
Autor(es): dc.creatorMorgano, Marcelo Antonio-
Autor(es): dc.creatorAlves, Monique Gabriela Chagas Faustino-
Autor(es): dc.creatorPassero, Luiz Felipe Domingues [UNESP]-
Autor(es): dc.creatorPontes, Daniel Lima-
Autor(es): dc.creatorTheodoro, Raquel Cordeiro-
Autor(es): dc.creatorArantes, Thales Domingos-
Autor(es): dc.creatorSabry, Diego Araujo-
Autor(es): dc.creatorSassaki, Guilherme Lanzi-
Autor(es): dc.creatorMelo-Silveira, Raniere Fagundes-
Autor(es): dc.creatorRocha, Hugo Alexandre Oliveira-
Data de aceite: dc.date.accessioned2022-02-22T00:27:11Z-
Data de disponibilização: dc.date.available2022-02-22T00:27:11Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/biom10091235-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/199369-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/199369-
Descrição: dc.descriptionCorn cob is an agricultural byproduct that produces an estimated waste burden in the thousands of tons annually, but it is also a good source of xylan, an important bioactive polysaccharide. Silver nanoparticles containing xylan (nanoxylan) were produced using an environmentally friendly synthesis method. To do this, we extracted xylan from corn cobs using an ultrasound technique, which was confirmed by both chemical and NMR analyses. This xylan contained xylose, glucose, arabinose, galactose, mannose, and glucuronic acid in a molar ratio of 50:21:14:9:2.5:2.5, respectively. Nanoxylan synthesis was analyzed using UV–vis spectroscopy at kmax = 469 nm and Fourier transform infrared spectroscopy (FT-IR), which confirmed the presence of both silver and xylan in the nanoxylan product. Dynamic light scattering (DLS) and atomic force microscopy (AFM) revealed that the nanoxylan particles were ~102.0 nm in size and spherical in shape, respectively. DLS also demonstrated that nanoxylan was stable for 12 months and coupled plasma optical emission spectrometry (ICP-OES) showed that the nanoxylan particles were 19% silver. Nanoxylan reduced Leishmania amazonensis promastigote viability with a half maximal inhibitory concentration (IC50) value of 25 µg/mL, while xylan alone showed no effective. Additionally, nanoxylan exhibited antifungal activity against Candida albicans (MIC = 7.5 µg/mL), C. parapsilosis (MIC = 7.5 µg/mL), and Cryptococcus neoformans (MIC = 7.5 µg/mL). Taken together, these data suggest that it is possible to synthesize silver nanoparticles using xylan and that these nanoxylan exert improved antileishmanial and antifungal activities when compared to the untreated polysaccharide or silver nitrate used for their synthesis. Thus, nanoxylan may represent a promising new class of antiparasitic agents for use in the treatment of these microorganisms.-
Descrição: dc.descriptionAssociation for Progressive Communications-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionMinistério da Ciência, Tecnologia, Inovações e Comunicações-
Descrição: dc.descriptionUniversidade Federal do Rio Grande do Norte-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartamento de Bioquímica Universidade Federal do Rio Grande do Norte-
Descrição: dc.descriptionDepartamento de Química Universidade Federal do Rio Grande do Norte-
Descrição: dc.descriptionCentro de Ciências e Qualidade dos Alimentos (CCQA) Instituto de Tecnologia dos Alimentos (ITAL)-
Descrição: dc.descriptionInstituto de Biociências Universidade Estadual de São Paulo (Unesp), Praça Infante Dom Henrique, s/n-
Descrição: dc.descriptionDepartamento de Bioquímica Universidade Federal do Paraná-
Descrição: dc.descriptionInstituto de Biociências Universidade Estadual de São Paulo (Unesp), Praça Infante Dom Henrique, s/n-
Descrição: dc.descriptionCNPq: 485813/2012-2-
Formato: dc.format1-21-
Idioma: dc.languageen-
Relação: dc.relationBiomolecules-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAgricultural byproduct-
Palavras-chave: dc.subjectAntiparasitic-
Palavras-chave: dc.subjectNanomaterials-
Palavras-chave: dc.subjectPolysaccharides-
Título: dc.titleGreen synthesis of antileishmanial and antifungal silver nanoparticles using corn cob xylan as a reducing and stabilizing agent-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.