Effect of different doses of 2,4-dichlorophenoxyacetic acid (2,4-d) on cardiac parameters in male Wistar rats

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Autor(es): dc.contributorUniversity of Western São Paulo (UNOESTE)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorDe Oliveira Mantovani, Raíssa-
Autor(es): dc.creatorPinheiro, Dyovana Gomes-
Autor(es): dc.creatorDe Oliveira, Geovana Letícia Fernandes-
Autor(es): dc.creatorPerrud, Stéfani Nobrega-
Autor(es): dc.creatorTeixeira, Giovana Rampazzo [UNESP]-
Autor(es): dc.creatorNai, Gisele Alborghetti-
Autor(es): dc.creatorVeras, Allice Santos Cruz [UNESP]-
Autor(es): dc.creatorde Almeida Tavares, Maria Eduarda [UNESP]-
Autor(es): dc.creatorde Oliveira Mendes, Leonardo-
Autor(es): dc.creatorPacagnelli, Francis Lopes-
Data de aceite: dc.date.accessioned2022-02-22T00:27:09Z-
Data de disponibilização: dc.date.available2022-02-22T00:27:09Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2019-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s11356-020-10699-y-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/199354-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/199354-
Descrição: dc.descriptionThe objective of this study was to evaluate the effects of different doses of 2,4-dichlorophenoxyacetic herbicide in rat hearts. Exposure was through rat food that was nebulized with the herbicide. Thirty adult male Wistar rats (200–300 g) were used. The diet was exposed to 2,4-D in two different doses (CG: control group 10 ml distilled water; LCG: low concentration group 3.71 × 10−3 g.ia/ha diluted in 10 ml saline at 0.9% and HCG: High concentration group 9.28 × 10−3 g.ia/ha diluted in 10 ml 0.9% saline). After 6 months of exposure, blood samples were collected for CKMB evaluation, and left ventricular fragments were analyzed by histological evaluation, fibrosis measurements, fractal dimension and immunohistochemistry (BAX, Bcl2, TNF-α and NF-kB). There were no significant changes in CK-MB concentration, histological parameters, fibrosis measurements and fractal dimension. Long-term oral consumption of food nebulized by the herbicide 2,4-D promoted an increase in BAX, Bcl-2/BAX, and cytoplasmic NF-kB in the nuclear area of the group that received the highest dose of the herbicide. This suggests that the herbicide induces cardiotoxicity.-
Descrição: dc.descriptionPostgraduate Animal Science Program University of Western São Paulo (UNOESTE)-
Descrição: dc.descriptionFaculty of Health Sciences Physiotherapy University of Western São Paulo (UNOESTE)-
Descrição: dc.descriptionFaculty of Science and Technology São Paulo State University (UNESP)-
Descrição: dc.descriptionFaculty of Science and Technology São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationEnvironmental Science and Pollution Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subject2,4-Dichlorophenocycetic-
Palavras-chave: dc.subjectApoptosis-
Palavras-chave: dc.subjectCardiotoxicity-
Palavras-chave: dc.subjectHerbicide-
Título: dc.titleEffect of different doses of 2,4-dichlorophenoxyacetic acid (2,4-d) on cardiac parameters in male Wistar rats-
Tipo de arquivo: dc.typelivro digital-
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