Atenção: Todas as denúncias são sigilosas e sua identidade será preservada.
Os campos nome e e-mail são de preenchimento opcional
Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.contributor | Universidade Federal de Minas Gerais (UFMG) | - |
Autor(es): dc.contributor | Universidade Federal de São Carlos (UFSCar) | - |
Autor(es): dc.creator | de Araújo Lopes, J. M. [UNESP] | - |
Autor(es): dc.creator | Benetti, F. [UNESP] | - |
Autor(es): dc.creator | Rezende, G. C. [UNESP] | - |
Autor(es): dc.creator | Souza, M. T. | - |
Autor(es): dc.creator | Conti, L. C. [UNESP] | - |
Autor(es): dc.creator | Ervolino, E. [UNESP] | - |
Autor(es): dc.creator | Jacinto, R. C. [UNESP] | - |
Autor(es): dc.creator | Zanotto, E. D. | - |
Autor(es): dc.creator | Cintra, L. T.A. [UNESP] | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:27:03Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:27:03Z | - |
Data de envio: dc.date.issued | 2020-12-11 | - |
Data de envio: dc.date.issued | 2020-12-11 | - |
Data de envio: dc.date.issued | 2019-12-31 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1111/iej.13382 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/199323 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/199323 | - |
Descrição: dc.description | Aim: To evaluate the biocompatibility, induction of mineralization and antimicrobial activity of experimental intracanal pastes based on two glass and glass-ceramic materials. Calcium hydroxide (Ca(OH)2) paste was used as the positive control. Methodology: The glass-ceramic powder [two-phased Biosilicate (BS-2P)] and F18 bioactive glass were mixed with distilled water (ratio 2 : 1), inserted in polyethylene tubes and implanted in the subcutaneous tissues of 16 rats. Empty tubes were used as negative control. After 7 and 30 days (n = 8), the rats were euthanized for haematoxylin–eosin, von Kossa, polarized light and osteopontin (OPN) immunolabeling analysis. Direct contact tests using a suspension of each paste were performed with Enterococcus faecalis planktonic cells to evaluate antimicrobial activity (24 h of contact), in a pilot study. The number of CFU mL−1 was calculated for each group. The antimicrobial analysis data were submitted to one-way anova and Tukey tests, whilst biocompatibility and immunohistochemical data were submitted to the Kruskal–Wallis and Dunn tests (P < 0.05). Results: Most specimens of the control, BS-2P and Ca(OH)2 groups were associated with moderate inflammation seven days following implantation, whilst F18 was associated with moderate to severe inflammation, without differences amongst the groups (P > 0.05). At 30 days, most specimens of control, F18 and BS-2P groups had mild inflammation, whilst Ca(OH)2 had mild to moderate inflammation; however, no differences were determined amongst the groups (P > 0.05). The fibrous capsule was thick at 7 days, becoming thin at 30 days. All pastes induced von Kossa-positive structures and were birefringent to polarized light. At seven days, the BS-2P group had significantly more OPN immunolabeling compared to the control and Ca(OH)2 groups (P < 0.05). At 30 days, the F18 group had significantly more OPN immunolabeling compared to the control and Ca(OH)2 groups (P < 0.05). All pastes reduced the total number of E. faecalis; however, the reduction was only significant when comparing BS-2P and Ca(OH)2 groups to the control (P < 0.05). Only calcium hydroxide eliminated E. faecalis. Conclusions: Experimental BS-2P and F18 pastes were biocompatible, stimulated biomineralization and induced significant OPN immunolabeling compared to Ca(OH)2. Only the BS-2P paste demonstrated antimicrobial activity comparable to Ca(OH)2. | - |
Descrição: dc.description | Endodontics Section Department of Preventive and Restorative Dentistry School of Dentistry São Paulo State University (Unesp) | - |
Descrição: dc.description | Endodontic Section Department of Restorative Dentistry School of Dentistry Universidade Federal de Minas Gerais | - |
Descrição: dc.description | Vitreous Materials Laboratory (LaMaV) Department of Materials Engineering Federal University of São Carlos (UFSCar) | - |
Descrição: dc.description | Department of Basic Science School of Dentistry São Paulo State University (Unesp) | - |
Descrição: dc.description | Endodontics Section Department of Preventive and Restorative Dentistry School of Dentistry São Paulo State University (Unesp) | - |
Descrição: dc.description | Department of Basic Science School of Dentistry São Paulo State University (Unesp) | - |
Idioma: dc.language | en | - |
Relação: dc.relation | International Endodontic Journal | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | bioactive glass | - |
Palavras-chave: dc.subject | bioceramics | - |
Palavras-chave: dc.subject | biocompatibility | - |
Palavras-chave: dc.subject | biomineralization | - |
Palavras-chave: dc.subject | osteopontin | - |
Título: dc.title | Biocompatibility, induction of mineralization and antimicrobial activity of experimental intracanal pastes based on glass and glass-ceramic materials | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
O Portal eduCAPES é oferecido ao usuário, condicionado à aceitação dos termos, condições e avisos contidos aqui e sem modificações. A CAPES poderá modificar o conteúdo ou formato deste site ou acabar com a sua operação ou suas ferramentas a seu critério único e sem aviso prévio. Ao acessar este portal, você, usuário pessoa física ou jurídica, se declara compreender e aceitar as condições aqui estabelecidas, da seguinte forma: