Green Synthesis of Antileishmanial and Antifungal Silver Nanoparticles Using Corn Cob Xylan as a Reducing and Stabilizing Agent

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorInstituto de Tecnologia dos Alimentos (ITAL)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade Federal do Paraná (UFPR)-
Autor(es): dc.creatorSilva Viana, Rony Lucas-
Autor(es): dc.creatorPereira Fidelis, Gabriel-
Autor(es): dc.creatorJane Campos Medeiros, Mayara-
Autor(es): dc.creatorAntonio Morgano, Marcelo-
Autor(es): dc.creatorGabriela Chagas Faustino Alves, Monique-
Autor(es): dc.creatorDomingues Passero, Luiz Felipe [UNESP]-
Autor(es): dc.creatorLima Pontes, Daniel-
Autor(es): dc.creatorCordeiro Theodoro, Raquel-
Autor(es): dc.creatorDomingos Arantes, Thales-
Autor(es): dc.creatorAraujo Sabry, Diego-
Autor(es): dc.creatorLanzi Sassaki, Guilherme-
Autor(es): dc.creatorFagundes Melo-Silveira, Raniere-
Autor(es): dc.creatorRocha, Hugo Alexandre Oliveira-
Data de aceite: dc.date.accessioned2022-02-22T00:27:02Z-
Data de disponibilização: dc.date.available2022-02-22T00:27:02Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-08-25-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/biom10091235-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/199314-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/199314-
Descrição: dc.descriptionCorn cob is an agricultural byproduct that produces an estimated waste burden in the thousands of tons annually, but it is also a good source of xylan, an important bioactive polysaccharide. Silver nanoparticles containing xylan (nanoxylan) were produced using an environmentally friendly synthesis method. To do this, we extracted xylan from corn cobs using an ultrasound technique, which was confirmed by both chemical and NMR analyses. This xylan contained xylose, glucose, arabinose, galactose, mannose, and glucuronic acid in a molar ratio of 50:21:14:9:2.5:2.5, respectively. Nanoxylan synthesis was analyzed using UV-vis spectroscopy at kmax = 469 nm and Fourier transform infrared spectroscopy (FT-IR), which confirmed the presence of both silver and xylan in the nanoxylan product. Dynamic light scattering (DLS) and atomic force microscopy (AFM) revealed that the nanoxylan particles were ~102.0 nm in size and spherical in shape, respectively. DLS also demonstrated that nanoxylan was stable for 12 months and coupled plasma optical emission spectrometry (ICP-OES) showed that the nanoxylan particles were 19% silver. Nanoxylan reduced Leishmania amazonensis promastigote viability with a half maximal inhibitory concentration (IC50) value of 25 μg/mL, while xylan alone showed no effective. Additionally, nanoxylan exhibited antifungal activity against Candida albicans (MIC = 7.5 μg/mL), C. parapsilosis (MIC = 7.5 μg/mL), and Cryptococcus neoformans (MIC = 7.5 μg/mL). Taken together, these data suggest that it is possible to synthesize silver nanoparticles using xylan and that these nanoxylan exert improved antileishmanial and antifungal activities when compared to the untreated polysaccharide or silver nitrate used for their synthesis. Thus, nanoxylan may represent a promising new class of antiparasitic agents for use in the treatment of these microorganisms.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartamento de Bioquímica, Universidade Federal do Rio Grande do Norte, Natal, RN, Rio Grande do Norte 59078-970, Brazil-
Descrição: dc.descriptionDepartamento de Química, Universidade Federal do Rio Grande do Norte, Natal, RN, Rio Grande do Norte 59078-970, Brazil-
Descrição: dc.descriptionCentro de Ciências e Qualidade dos Alimentos (CCQA) Instituto de Tecnologia dos Alimentos (ITAL)-
Descrição: dc.descriptionInstituto de Biociências Universidade Estadual de São Paulo (Unesp) Praça Infante Dom Henrique, s/n-
Descrição: dc.descriptionDepartamento de Bioquímica Universidade Federal do Paraná PR-
Descrição: dc.descriptionInstituto de Biociências Universidade Estadual de São Paulo (Unesp) Praça Infante Dom Henrique, s/n-
Descrição: dc.descriptionCNPq: 485813/2012-2-
Idioma: dc.languageen-
Relação: dc.relationBiomolecules-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectagricultural byproduct-
Palavras-chave: dc.subjectantiparasitic-
Palavras-chave: dc.subjectnanomaterials-
Palavras-chave: dc.subjectpolysaccharides-
Título: dc.titleGreen Synthesis of Antileishmanial and Antifungal Silver Nanoparticles Using Corn Cob Xylan as a Reducing and Stabilizing Agent-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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