Salivary Microbiological and Gingival Health Status Evaluation of Adolescents With Overweight and Obesity: A Cluster Analysis

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Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorSão Francisco University-
Autor(es): dc.contributorUniversidade Federal de São Paulo (UNIFESP)-
Autor(es): dc.contributorABC Medical School-
Autor(es): dc.creatorAraujo, Darlle Santos-
Autor(es): dc.creatorKlein, Marlise Inêz [UNESP]-
Autor(es): dc.creatorScudine, Kelly Guedes de Oliveira-
Autor(es): dc.creatorde Sales Leite, Luana [UNESP]-
Autor(es): dc.creatorParisotto, Thais M.-
Autor(es): dc.creatorFerreira, Caroline Marcantonio-
Autor(es): dc.creatorFonseca, Fernando Luiz Affonso-
Autor(es): dc.creatorPerez, Matheus Moreira-
Autor(es): dc.creatorCastelo, Paula Midori-
Data de aceite: dc.date.accessioned2022-02-22T00:26:55Z-
Data de disponibilização: dc.date.available2022-02-22T00:26:55Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-07-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3389/fped.2020.00429-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/199272-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/199272-
Descrição: dc.descriptionGiven the high prevalence of obesity in children and adolescents, the investigation of early markers is of clinical importance to better manage this condition. Thus, the aim was to evaluate the cross-sectional relationship between salivary microbiota, gingival health status, and excess weight in adolescents. A total of 248 students (14–17 y; 119 girls) were included, free of caries lesions and periodontal pockets. Physical examination included measures of height, weight, and body fat percentage (%BF). Oral examination was performed to gather information on dental (DMFT index) and gingival health status. Unstimulated saliva was submitted to qPCR reactions to quantify Streptococcus mutans, Porphyromonas gingivalis, Bifidobacteria, and Streptococcus pneumoniae percentages and the NFKappaB expression. Two-way ANOVA was applied considering group (normal-weight/overweight/obesity) and sex factors, in addition to cluster analysis. Group effect was significant for %S. mutans (partial eta2 = 0.20; p < 0.001) and %Bifidobacteria (partial eta2 = 0.19; p < 0.001), with overweight and obesity groups showing the highest levels compared to normal-weight ones, with no significant sex effect. There was no difference in the frequency of gingivitis, P. gingivalis, and S. pneumoniae percentages or NFKappaB expression between groups. Cluster analysis generated three clusters according to body fat accumulation: “Higher %BF,” “Moderate %BF,” and “Lower %BF.” “Higher %BF” cluster was characterized by higher body fat percentage and higher salivary %Bifidobacteria, while cluster “Lower %BF” was characterized by lower body fat percentage and lower frequency of gingivitis (“Moderate %BF” cluster was the contrast). According to nutritional status, a difference in salivary S. mutans and Bifidobacteria percentages was found, with overweight or obesity adolescents showing the highest percentages than normal-weight ones. Besides, a positive relationship between body fat accumulation and Bifidobacteria count was observed, indicating a possible interaction between oral bacteria communities and weight gain.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Pediatric Dentistry Universidade Estadual de Campinas (UNICAMP-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics São Paulo State University (UNESP) School of Dentistry-
Descrição: dc.descriptionLaboratory of Molecular Biology of Microorganisms São Francisco University-
Descrição: dc.descriptionDepartment of Pharmaceutical Sciences Universidade Federal de São Paulo (UNIFESP-
Descrição: dc.descriptionDepartment of Pathology ABC Medical School-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics São Paulo State University (UNESP) School of Dentistry-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionFAPESP: 2014/24804-4-
Descrição: dc.descriptionFAPESP: 2017/26400-6-
Idioma: dc.languageen-
Relação: dc.relationFrontiers in Pediatrics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectadolescent-
Palavras-chave: dc.subjectmicrobiota-
Palavras-chave: dc.subjectobesity-
Palavras-chave: dc.subjectoral health-
Palavras-chave: dc.subjectsaliva-
Título: dc.titleSalivary Microbiological and Gingival Health Status Evaluation of Adolescents With Overweight and Obesity: A Cluster Analysis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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