High- and moderate-intensity training modify LPS-induced ex-vivo interleukin-10 production in obese men in response to an acute exercise bout

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversity Center of Maringa (UniCesumar)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorFederal University of Health Sciences of Porto Alegre (UFCSPA)-
Autor(es): dc.creatorGerosa-Neto, José [UNESP]-
Autor(es): dc.creatorMonteiro, Paula Alves [UNESP]-
Autor(es): dc.creatorInoue, Daniela Sayuri [UNESP]-
Autor(es): dc.creatorAntunes, Barbara Moura [UNESP]-
Autor(es): dc.creatorBatatinha, Helena-
Autor(es): dc.creatorDorneles, Gilson Pires-
Autor(es): dc.creatorPeres, Alessandra-
Autor(es): dc.creatorRosa-Neto, José Cesar-
Autor(es): dc.creatorLira, Fabio Santos [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:26:54Z-
Data de disponibilização: dc.date.available2022-02-22T00:26:54Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.cyto.2020.155249-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/199264-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/199264-
Descrição: dc.descriptionThe aim of this study was to evaluate the inflammatory (peripheral and lipopolysaccharide (LPS)-stimulated released from whole blood) and metabolic (glucose and insulin) profile of inactive obese men in response to two isoenergetic models of aerobic exercise training (~300 kcal each exercise session). Twenty-two participants (28.7 ± 1.6 years; BMI = 34.4 ± 0.1 kg/m2) were randomized into two groups: I) HIIT: high-intensity interval training (10× 1 bout: 1 min − 100% Maximal Aerobic Velocity) or II) MICT: moderate-intensity continuous training (65% Maximal Aerobic Velocity; kcal equal to HIIT). Both groups trained three times per week for 6-weeks. Fasting blood samples were collected before and 0, 30, and 60 min after exercise during the first and last training sessions for evaluation of: I) MIP-1ɑ, insulin, glucose, visceral and subcutaneous fat depots, oral glucose tolerance test, and homeostatic model assessment of insulin resistance (HOMA-IR) index; II) Peripheral (TNF-α, IL-6, and IL-10) and LPS-stimulated release of TNF-α and IL-10 were analyzed before, 0, and 60 min after sessions. IL-6 concentration remained elevated up to 60-min after the acute exercise session (p < 0.001), and IL-10 concentration was higher after 30 and 60-min (p = 0.001) compared to rest, independent of training period and protocol. AUC of IL-10 presented effect of type of training (p = 0.023) with MICT group showed significantly higher values than the HIIT. The ex-vivo assay showed higher IL-10 secretion in response to LPS immediately (p = 0.003) after both acute MICT and HIIT exercise sessions, independent of training period. Fifteen subjects presented decreased HOMA-IR after 6-weeks and seven presented an increase in this index. When we excluded the two least responsive subjects, it was possible to observe a decrease in HOMA-IR (p = 0.020) after training. Taken together, our results suggest that both HIIT and MICT (with same energy expenditure) promote similar effects on HOMA-IR and led to elevations in IL-10 production in LPS-stimulated whole blood, suggesting that leukocytes had an enhanced ability to secrete anti-inflammatory cytokines after the exercise bout.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionExercise and Immunometabolism Research Group Post graduation Program in Movement Sciences Department of Physical Education Universidade Estadual Paulista (UNESP)-
Descrição: dc.descriptionPhysical Education Physiotherapy University Center of Maringa (UniCesumar)-
Descrição: dc.descriptionDepartment of Cell and Developmental Biology Institute of Biomedical Sciences University of São Paulo (USP)-
Descrição: dc.descriptionDepartment of Health Basic Science Federal University of Health Sciences of Porto Alegre (UFCSPA)-
Descrição: dc.descriptionExercise and Immunometabolism Research Group Post graduation Program in Movement Sciences Department of Physical Education Universidade Estadual Paulista (UNESP)-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionFAPESP: 2015/22402-9-
Descrição: dc.descriptionFAPESP: 2016/16712-8-
Idioma: dc.languageen-
Relação: dc.relationCytokine-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAerobic training-
Palavras-chave: dc.subjectAnti-inflammatory-
Palavras-chave: dc.subjectIsoenergetic training-
Palavras-chave: dc.subjectShort-term training-
Título: dc.titleHigh- and moderate-intensity training modify LPS-induced ex-vivo interleukin-10 production in obese men in response to an acute exercise bout-
Tipo de arquivo: dc.typelivro digital-
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