Peanut skin polyphenols inhibit toxicity induced by advanced glycation end-products in RAW264.7 macrophages

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Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversity of Nebraska-Lincoln-
Autor(es): dc.creatorFernandes, Annayara Celestina Ferreira-
Autor(es): dc.creatorVieira, Natália Carolina [UNESP]-
Autor(es): dc.creatorSantana, Ádina Lima de-
Autor(es): dc.creatorGandra, Renata Luana de Pádua-
Autor(es): dc.creatorRubia, Camila-
Autor(es): dc.creatorCastro-Gamboa, Ian [UNESP]-
Autor(es): dc.creatorMacedo, Juliana Alves-
Autor(es): dc.creatorMacedo, Gabriela Alves-
Data de aceite: dc.date.accessioned2022-02-22T00:26:53Z-
Data de disponibilização: dc.date.available2022-02-22T00:26:53Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.fct.2020.111619-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/199260-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/199260-
Descrição: dc.descriptionThis is the first work to use a polyphenolic fraction derived from peanut skin to attenuate the toxicity induced by advanced glycation-end products (AGEs) in RAW264.7 macrophages. The RAW264.7 cells were stimulated by AGEs using the bovine serum albumin-fructose (BSA-FRU), bovine serum albumin-methylglyoxal (BSA-MGO) and arginine-methylglyoxal (ARG-MGO) models. The AGEs increased considerably the levels of reactive oxygen species and the gene expression of proinflammatory cytokines interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and nitric oxide. Twenty-eight polyphenols, including catechin, phenolic acids, and resveratrol were annotated in peanut skin extract (PSE) with the use of ultra-performance liquid chromatography coupled to quadrupole time of flight mass spectrometry (UPLC-QTOF/MSE) and to the UNIFI Scientific Information System. The administration of PSE at 100 and 150 μg/mL significantly inhibited oxidative stress, by suppressing the production of reactive oxygen species up to 70% and reducing the production of nitric oxide, IL-6 and TNF-α up to 1.7-, 10- and 107-fold, respectively.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionSchool of Food Engineering Food and Nutrition Department University of Campinas (UNICAMP)-
Descrição: dc.descriptionCenter for Bioassays Biosynthesis and Ecophysiology of Natural Products (NuBBE) Institute of Chemistry (ICAr) Sao Paulo State University (UNESP)-
Descrição: dc.description264 Food Innovation Center University of Nebraska-Lincoln, 1901 N 21st Street-
Descrição: dc.descriptionCenter for Bioassays Biosynthesis and Ecophysiology of Natural Products (NuBBE) Institute of Chemistry (ICAr) Sao Paulo State University (UNESP)-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionCNPq: 140884/2016-5-
Descrição: dc.descriptionFAPESP: 2018/24868-3-
Idioma: dc.languageen-
Relação: dc.relationFood and Chemical Toxicology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAdvanced glycation end-products-
Palavras-chave: dc.subjectInflammation-
Palavras-chave: dc.subjectMethylglyoxal-
Palavras-chave: dc.subjectPeanut skin-
Palavras-chave: dc.subjectPhenolic compounds-
Palavras-chave: dc.subjectRAW264.7 macrophages-
Título: dc.titlePeanut skin polyphenols inhibit toxicity induced by advanced glycation end-products in RAW264.7 macrophages-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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