Nitric oxide in the insular cortex modulates baroreflex responses in a cGMP-independent pathway

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorFaculty of Medicine – Federal University of Lavras-
Autor(es): dc.creatorFerreira-Junior, Nilson C.-
Autor(es): dc.creatorCrestani, Carlos C. [UNESP]-
Autor(es): dc.creatorLagatta, Davi C.-
Autor(es): dc.creatorResstel, Leonardo B.M.-
Autor(es): dc.creatorCorrea, Fernando M.A.-
Autor(es): dc.creatorAlves, Fernando H.F.-
Data de aceite: dc.date.accessioned2022-02-22T00:26:44Z-
Data de disponibilização: dc.date.available2022-02-22T00:26:44Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-11-14-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.brainres.2020.147037-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/199202-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/199202-
Descrição: dc.descriptionInsular cortex is a brain structure involved in the modulation of autonomic activity and cardiovascular function. The nitric oxide/cyclic guanosine-3′,5′-monophosphate pathway is a prominent signaling mechanism in the central nervous system, controlling behavioral and physiological responses. Nevertheless, despite evidence regarding the presence of nitric oxide-synthesizing neurons in the insular cortex, its role in the control of autonomic and cardiovascular function has never been reported. Thus, the present study aimed to investigate the involvement of nitric oxide/cyclic guanosine-3′,5′-monophosphate pathway mediated by neuronal nitric oxide synthase (nNOS) activation within the insular cortex in the modulation of baroreflex responses in unanesthetized rats. For this, we evaluated the effect of bilateral microinjection of either the nitric oxide scavenger carboxy-PTIO, the selective neuronal nitric oxide synthase inhibitor Nω-Propyl-L-arginine or the soluble guanylate cyclase inhibitor ODQ into the insular cortex on the bradycardia evoked by blood pressure increases in response to intravenous infusion of phenylephrine, and the tachycardia caused by blood pressure decreases evoked by intravenous infusion of sodium nitroprusside. Bilateral microinjection of either NPLA or carboxy-PTIO into the insular cortex increased the reflex bradycardic response, whereas the reflex tachycardia was decreased by these treatments. Bilateral microinjection of the soluble guanylate cyclase inhibitor into the insular cortex did not affect any parameter of baroreflex function evaluated. Overall, our findings provide evidence that insular cortex nitrergic signaling, acting via neuronal nitric oxide synthase, plays a prominent role in control of baroreflex function. However, control of reflex responses seems to be independent of soluble guanylate cyclase activation.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)-
Descrição: dc.descriptionDepartment of Pharmacology School of Medicine of Ribeirão Preto University of São Paulo-
Descrição: dc.descriptionLaboratory of Pharmacology School of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Health Sciences Faculty of Medicine – Federal University of Lavras-
Descrição: dc.descriptionLaboratory of Pharmacology School of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionCNPq: 141992/2016-6-
Descrição: dc.descriptionFAPESP: 2015/05922-9-
Descrição: dc.descriptionCNPq: 456405/2014-3-
Descrição: dc.descriptionFAPEMIG: APQ-01316-16-
Idioma: dc.languageen-
Relação: dc.relationBrain Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBaroreflex-
Palavras-chave: dc.subjectGMPc-
Palavras-chave: dc.subjectInsular cortex-
Palavras-chave: dc.subjectNitric oxide-
Título: dc.titleNitric oxide in the insular cortex modulates baroreflex responses in a cGMP-independent pathway-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.