Ecotoxicological assessment of chemotherapeutic agents using toxicity tests with embryos of Mellita quinquiesperforata

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade do Algarve-
Autor(es): dc.creatorMello, Luiza Costa [UNESP]-
Autor(es): dc.creatorda Fonseca, Taina Garcia [UNESP]-
Autor(es): dc.creatorDenis Moledode de Souza, Abessa [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:26:39Z-
Data de disponibilização: dc.date.available2022-02-22T00:26:39Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.marpolbul.2020.111493-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/199173-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/199173-
Descrição: dc.descriptionThe consumption of anticancer agents has increased in the recent decades, and these substances may be present in sewage. Consequently, they may reach the environment when sanitation infrastructure is ineffective. This study evaluated the toxicity of three anticancer agents—Tamoxifen (TAM), Cisplatin (CisPt), and Cyclophosphamide (CP)—on the development of embryos of the sand-dollar Mellita quinquiesperforata. Adult individuals were collected in sandy beaches, and gametes were obtained. Freshly-fertilized eggs were exposed to increasing sets of concentrations of each compound, and the effective concentrations needed to cause a 50% effect in the organisms (EC50) were calculated. The three compounds were toxic, and their EC50 values were 16.78 ± 2.42 ng·L−1 (TAM), 27.20 ± 38.26 ng·L−1 (CisPt), and 101.82 ± 70.96 ng·L−1 (CP). There is no information on the environmental levels of these compounds in Brazil, but as they were already detected in ng·L−1 levels worldwide, it can be expected that these substances pose environmental risks to the marine biota.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionCenter of Studies on Aquatic Pollution and Ecoxicology (NEPEA) São Paulo State University - UNESP-
Descrição: dc.descriptionCentre for Marine and Environmental Research (CIMA) Universidade do Algarve, Campus de Gambelas-
Descrição: dc.descriptionCenter of Studies on Aquatic Pollution and Ecoxicology (NEPEA) São Paulo State University - UNESP-
Descrição: dc.descriptionFAPESP: 18/19123-9-
Descrição: dc.descriptionCNPq: 202360/2014-8-
Descrição: dc.descriptionCNPq: 308533/2018-6-
Descrição: dc.descriptionCNPq: 311609/2014-7-
Idioma: dc.languageen-
Relação: dc.relationMarine Pollution Bulletin-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectChemotherapeutics-
Palavras-chave: dc.subjectEchinoderms-
Palavras-chave: dc.subjectEcotoxicity-
Palavras-chave: dc.subjectMarine pollution-
Palavras-chave: dc.subjectPharmaceuticals-
Título: dc.titleEcotoxicological assessment of chemotherapeutic agents using toxicity tests with embryos of Mellita quinquiesperforata-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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