Intra-operative methadone effect on quality of recovery compared with morphine following laparoscopic gastroplasty: a randomised controlled trial

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorSanta Genoveva Hospital Complex-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorQueens University-
Autor(es): dc.creatorPontes, J. P.J.-
Autor(es): dc.creatorBraz, F. R.-
Autor(es): dc.creatorMódolo, N. S.P. [UNESP]-
Autor(es): dc.creatorMattar, L. A.-
Autor(es): dc.creatorSousa, J. A.G.-
Autor(es): dc.creatorNavarro e Lima, L. H.-
Data de aceite: dc.date.accessioned2022-02-22T00:26:37Z-
Data de disponibilização: dc.date.available2022-02-22T00:26:37Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2019-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/anae.15173-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/199157-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/199157-
Descrição: dc.descriptionThe effect of intra-operative intravenous methadone on quality of postoperative recovery was compared with morphine after laparoscopic gastroplasty. We included 137 adult patients with a body mass index > 35 kg.m−2 who underwent bariatric surgery. Patients were allocated at random to receive either intra-operative methadone (n = 69) or morphine (n = 68). All patients received the same postoperative care and analgesia. The primary outcome of postoperative quality of recovery was assessed using the Quality of Recovery-40 questionnaire total score 24 h after surgery. Secondary outcomes were assessed in the post-anaesthesia care unit the night of the day of surgery (T1), in the morning after surgery (T2); and at night on the day following surgery (T3). The median (IQR [range]) total Quality of Recovery-40 questionnaire score of 194 (190–197 [165–200]) was higher (p < 0.0001) in the methadone group compared with the score of 181 (174–185.5 [121–200]) in the morphine group. In the post-anaesthesia care unit, the pain burden; incidence of nausea and vomiting; rescue morphine dose; and time to discharge, were significantly lower in the methadone group. On the ward, the methadone group had a lower: incidence of rescue morphine requests at T1 (5.8 vs. 54.4%, p < 0.0001) and T2 (0 vs. 20.1%, p < 0.0001); and incidence of nausea (21.7 vs. 41.2%, p = 0.014), compared with the morphine group. We conclude that intra-operative intravenous methadone improved quality of recovery in patients who underwent laparoscopic gastroplasty, compared with intra-operative morphine. Methadone also reduced postoperative pain, postoperative opioid consumption and the incidence of opioid-related adverse events.-
Descrição: dc.descriptionDepartment of Anaesthesiology Santa Genoveva Hospital Complex-
Descrição: dc.descriptionBotucatu School of Medicine UNESP-
Descrição: dc.descriptionDepartment of Surgery Santa Genoveva Hospital Complex-
Descrição: dc.descriptionDepartment of Anaesthesia Queens University-
Descrição: dc.descriptionBotucatu School of Medicine UNESP-
Idioma: dc.languageen-
Relação: dc.relationAnaesthesia-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbariatric surgery-
Palavras-chave: dc.subjectmethadone-
Palavras-chave: dc.subjectmorbid-
Palavras-chave: dc.subjectobesity-
Palavras-chave: dc.subjectpatient reported outcome measures-
Palavras-chave: dc.subjectquality measures: patient care-
Título: dc.titleIntra-operative methadone effect on quality of recovery compared with morphine following laparoscopic gastroplasty: a randomised controlled trial-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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