Antibody mediated osseous regeneration: A new strategy for bioengineering

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorAlfenas Federal University (Unifal-MG)-
Autor(es): dc.creatorCoelho, Fernanda [UNESP]-
Autor(es): dc.creatorDe Oliveira Capote, Ticiana Sidorenko [UNESP]-
Autor(es): dc.creatorDe Medeiros, Marcell Costa [UNESP]-
Autor(es): dc.creatorPigossi, Suzane Cristina-
Data de aceite: dc.date.accessioned2022-02-22T00:26:35Z-
Data de disponibilização: dc.date.available2022-02-22T00:26:35Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2019-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/978-3-030-34471-9_18-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/199141-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/199141-
Descrição: dc.descriptionThis chapter provides a brief review of bone biology and metabolism, focusing on the regenerative potential of bone tissues. In this context, we discussed the main clinical approaches to enhance bone regeneration, concentrating on an innovative approach referred to as antibody-mediated osseous regeneration (AMOR). Bone morphogenetic proteins (BMPs) are some of the most relevant osteoinductive factors in the demineralized bone matrix. The main role of BMPs is the recruitment and differentiation of mesenchymal cells into an osteogenic lineage, resulting in new bone formation. As an alternative for the BMP-2 exogenous administration of an osteoinductive growth factor, the use of immobilized anti-BMP-2 antibodies in matrices has been proposed to capture the endogenous protein. The captured endogenous BMP-2 would be able to induce osteogenic differentiation of osteoprogenitor stem cells and improve the bone formation. In general, the association of anti-BMP-2 mAb with a scaffold has demonstrated success in new bone formation in different in vivo models with no evidence of adverse reactions.-
Descrição: dc.descriptionDepartment of Morphology School of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Clinics and Surgery School of Dentistry Alfenas Federal University (Unifal-MG)-
Descrição: dc.descriptionDepartment of Morphology School of Dentistry São Paulo State University (UNESP)-
Formato: dc.format477-488-
Idioma: dc.languageen-
Relação: dc.relationRacing for the Surface: Antimicrobial and Interface Tissue Engineering-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntibodies-
Palavras-chave: dc.subjectBone morphogenetic proteins-
Palavras-chave: dc.subjectBone regeneration-
Palavras-chave: dc.subjectOsteoconductive-
Palavras-chave: dc.subjectOsteogenic-
Palavras-chave: dc.subjectOsteoinductive-
Palavras-chave: dc.subjectScaffold-
Palavras-chave: dc.subjectStem cells-
Título: dc.titleAntibody mediated osseous regeneration: A new strategy for bioengineering-
Aparece nas coleções:Repositório Institucional - Unesp

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